Ann Clin Microbiol 2020;23:81-92. Epidemiological Study of an Outbreak of KPC-2-producing Klebsiella pneumoniae in a Tertiary Hospital in Korea
| Characteristic | Total (n = 100) No. (%) | Pulsotype A (n = 31) No. (%) | Pulsotype B (n = 63) No. (%) | Others (n = 6) No. (%) | P-value* |
|---|---|---|---|---|---|
| Age (yr)† | 69.0 [60.1-77.3] | 69.0 [60.0-78.0] | 70.0 [62.0-76.5] | 67.5 [53.0-87.0] | 0.974 |
| Male | 56 (56.0) | 20 (64.5) | 33 (52.4) | 3 (50.0) | 0.371 |
| Comorbidity | |||||
| Cardiovascular disease | 15 (15.0) | 7 (22.6) | 7 (11.1) | 1 (16.7) | 0.246 |
| Cerebrovascular disease | 10 (10.0) | 4 (12.9) | 6 (9.5) | 0 (0.0) | 0.886 |
| Diabetes mellitus | 13 (13.0) | 4 (12.9) | 8 (12.7) | 1 (16.7) | 0.999 |
| End-stage renal disease | 6 (6.0) | 2 (6.5) | 4 (6.3) | 0 (0.0) | 0.999 |
| Chronic liver disease | 4 (4.0) | 2 (6.5) | 2 (3.2) | 0 (0.0) | 0.844 |
| Malignancy | 55 (55.0) | 21 (67.7) | 31 (49.2) | 3 (50.0) | 0.139 |
| Charlson comorbidity index† | 2.0 [1.0-6.0] | 3.0 [2.0-6.0] | 2.0 [1.0-6.0] | 1.5 [0.3-3.0] | |
| Specimen | 0.163 | ||||
| Sputum | 37 (37.0) | 15 (48.4) | 21 (33.3) | 1 (16.7) | |
| Urine | 22 (22.0) | 3 (9.7) | 18 (28.6) | 1 (16.7) | |
| Pus | 15 (15.0) | 3 (9.7) | 11 (17.5) | 1 (16.7) | |
| Surveillance | 13 (13.0) | 5 (16.1) | 6 (9.5) | 2 (33.3) | |
| Genital | 7 (7.0) | 2 (6.5) | 5 (7.9) | 0 (0.0) | |
| Blood | 6 (6.0) | 3 (9.7) | 2 (3.2) | 1 (16.7) | |
| Colonization | 37 (37.0) | 9 (29.0) | 23 (36.5) | 5 (83.3) | 0.626 |
| Admission | 0.762 | ||||
| Out-patient department | 2 (2.0) | 0 (0.0) | 0 (0.0) | 2 (33.3) | |
| General wards | 77 (77.0) | 23 (74.2) | 50 (79.4) | 4 (66.7) | |
| Intensive care units | 21 (21.0) | 8 (25.8) | 13 (20.6) | 0 (0.0) | |
| Transfer-in | 21 (21.0) | 7 (22.6) | 10 (15.9) | 4 (66.7) | 0.798 |
| Clinic | 6 (6.0) | 3 (9.7) | 3 (4.8) | 0 (0.0) | |
| General hospital | 9 (9.0) | 2 (6.5) | 4 (6.3) | 3 (50.0) | |
| Geriatric hospital | 6 (6.0) | 2 (6.5) | 3 (4.8) | 1 (16.7) | |
| 30-day mortality | 25 (25.0) | 10 (32.3) | 13 (20.6) | 2 (33.3) | 0.328 |
| In-hospital mortality | 37 (37.0) | 15 (48.4) | 20 (31.7) | 2 (33.3) | 0.180 |
| Pulsotype | |||||
| A | 31 (31.0) | – | – | – | |
| B | 63 (63.0) | – | – | – | |
| Others | 6 (6.0) | – | – | – | |
*P-value was calculated comparing two groups including pulsotype A and pulsotype B by Fisher’s exact test and Mann Whitney U test in categorical variables and continuous variables, respectively.
†Mean [interquartile range].