Ann Clin Microbiol 2020;23:125-134. Performance of Modified-EUCAST Rapid Direct Antimicrobial Susceptibility Testing on Clinical Urine Samples
| Antimicrobial agents | Modified-EUCAST rapid direct AST | Conventional AST | Unweighted kappa (95% CI) | Weighted kappa (95% CI) | |||||
|---|---|---|---|---|---|---|---|---|---|
| S | I | R | S | I | R | ||||
| Ampicillin | 12 | 3 | 88 | 12 | 0 | 91 | 0.83 (0.77 – 1) | 0.89 (0.77 – 1) | |
| Piperacillintazobactam | 91 | 8 | 4 | 86 | 8 | 9 | 0.66 (0.47 – 0.83) | 0.68 (0.50 – 0.86 ) | |
| Cefazolin | 44 | 0 | 59 | 41 | 0 | 62 | 0.90 (0.81 – 0.99) | 0.90 (0.81 – 0.99 ) | |
| Aztreonam | 65 | 5 | 33 | 67 | 0 | 36 | 0.84 (0.74 – 0.94 ) | 0.89 (0.80 – 0.97 ) | |
| Ceftazidime | 61 | 14 | 28 | 69 | 1 | 33 | 0.74 (0.62 – 0.85 ) | 0.84 (0.75 – 0.92 ) | |
| Cefotaxime | 50 | 6 | 47 | 54 | 3 | 46 | 0.89 (0.81 – 0.97) | 0.93 (0.876 – 0.99) | |
| Cefoxitin | 77 | 3 | 23 | 70 | 8 | 25 | 0.76 (0.63 – 0.88 ) | 0.86 (0.78 – 0.94) | |
| Cefepime | 79 | 0 | 24 | 80 | 6 | 17 | 0.73 (0.59 – 0.88 ) | 0.80 (0.67 – 0.92 ) | |
| Ertapenem | 100 | 2 | 1 | 98 | 1 | 4 | 0.49 (0.18 – 0.79 ) | 0.60 (0.29 – 0.92) | |
| Imipenem | 99 | 2 | 2 | 93 | 6 | 4 | 0.40 (0.08 – 0.73) | 0.48 (0.12 – 0.83) | |
| Gentamicin | 75 | 1 | 27 | 75 | 1 | 27 | 0.93 (0.85 – 1) | 0.95 (0.89 – 1) | |
| Amikacin | 101 | 1 | 1 | 103 | 0 | 0 | – | – | |
| Ciprofloxacin | 34 | 21 | 48 | 45 | 10 | 48 | 0.76 (0.66 – 0.87 ) | 0.85 (0.78 – 0.92) | |
| Cotrimoxazole | 56 | 1 | 46 | 57 | 0 | 46 | 0.90 (0.82 – 0.99 ) | 0.91 (0.83 – 0.99) | |
| Tigecycline | 96 | 0 | 7 | 92 | 2 | 9 | 0.52 (0.26 – 0.77) | 0.55 (0.29 – 0.82 ) | |
Abbreviation: EUCAST, European committee on antimicrobial susceptibility testing; AST, antimicrobial susceptibility test; S, susceptible; I, intermediate; R, resistant; CI, confidence interval.