Ann Clin Microbiol 2020;23:191-199. Causes and Clinical Relevance of Inconclusive SARS-CoV-2 Real-Time Reverse TranscriptionPCR Test Results

Table 1. Summary of rRT-PCR test producing inconclusive results from 11 COVID-19 patients
PatientAnti-COVID-19 treatmentDays from diagnosis toCt values of the initial inconclusive resultDays and number of consecutive test results from initial inconclusive results to negative conversion
AdmissionInitial inconclusive resultERdRpNDaysPosIncNeg
1N/A09N/D35.3536.5211053
2Lopinavir/ritonavir6635.435.28N/D11258
3N/A021N/DN/D38.7711331
4ECMO, steroid61532.99N/D37.7410666
5Lopinavir/ritonavir, Camostat mesylate, HCQ21235.71N/DN/D4032
6Camostat mesylate015N/D38.737.355122
7HCQ0533.65N/D34.56N/A*N/A*N/A*N/A*
8N/A6876N/DN/D38.692001
9Plasma treatment01437.1238.22N/D3302
10Lopinavir/ritonavir, HCQ, plasma treatment110N/D38.95N/D5306
11N/A00†N/DN/D36.91N/A†N/A†N/A†N/A†

*Drop out because transferred to another hospital before negative conversion.
†Diagnosis was made in retesting on same day and there was no further test owing to admission to another hospital.
Abbreviations: rRT-PCR, real-time reverse transcription-polymerase chain reaction; COVID-19, coronavirus disease 2019; Ct, threshold cycle; RdRp, RNA-dependent RNA polymerase gene; E, envelope gene; N, nucleocapsid gene; N/A, not applicable/available; ND, not detected; Pos, positive test; Inc, inconclusive test; Neg, negative test; ECMO, extracorporeal membrane oxygenation; HCQ, hydroxychloroquine.