Ann Clin Microbiol 2021;24:83-96. Evaluation of Five Automated Urine Analyzers as Screening Instruments for Enhancing Diagnostic Efficiency in Urinary Tract Infection

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Table 2. Diagnostic performances of automated urine sediment analyzers in urinary tract infection
Variable Sensitivity (%) Specificity (%) PPV (%) NPV (%)
M F P-value M F P-value M F P-value M F P-value
LE
  UF-5000 56.5 45.8 0.454 69.7 58.7 0.021* 13.1 25.6 0.039* 95.2 77.8 <0.001*
  UAS800 52.2 39.6 0.444 72.2 60.6 0.014* 13.2 23.8 0.056 94.9 77.0 <0.001*
  Cobas®u701 52.2 47.9 0.803 69.0 58.1 0.028* 12.0 26.1 0.015* 94.7 78.3 <0.001*
  iQ®200SPRINT 39.1 39.6 0.999 82.5 61.3 0.018* 10.3 24.1 0.023* 93.6 76.6 <0.001*
URiSCAN® PlusScope 34.8 33.3 0.999 74.6 67.1 0.097 10.0 23.9 0.027* 93.4 76.5 <0.001*
Nitrite
  UF-5000 21.7 27.1 0.774 98.9 97.4 0.249 62.5 76.5 0.661 94.0 81.2 0.001*
  UAS800 26.1 25.0 0.999 96.1 95.5 0.803 35.3 63.2 0.181 94.1 80.4 <0.001*
  Cobas® u701 30.4 27.1 0.784 92.6 94.2 0.693 25.0 59.1 0.466 94.3 80.7 <0.001*
  iQ®200SPRINT 21.7 27.1 0.774 98.9 98.1 0.431 62.5 81.3 0.667 94.0 81.3 0.001*
URiSCAN® PlusScope 21.7 25.0 0.999 98.9 98.7 0.999 62.5 85.7 0.642 94.0 81.0 <0.001*
WBC†
  UF-5000 60.9 60.4 0.590 81.3 75.5 0.175 20.9 43.3 0.009* 96.3 86.0 <0.001*
  UAS800 56.5 39.6 0.138 84.2 77.4 0.054 22.4 35.2 0.149 96.0 80.5 <0.001*
  Cobas® u701 56.5 41.7 0.138 84.5 72.9 0.054 22.8 32.3 0.119 96.0 80.1 <0.001*
  iQ®200SPRINT 60.9 54.2 0.620 73.6 67.7 0.796 15.7 34.2 0.007* 95.9 82.7 <0.001*
URiSCAN® PlusScope 43.5 37.5 0.796 93.3 86.5 0.023* 34.5 46.2 0.455 95.3 81.7 <0.001*
Bacteria‡,§
  UF-1000 56.5 62.5 0.796 93.3 83.2 0.002* 40.6 53.6 0.461 96.4 87.8 <0.001*
  UF-5000 43.5 52.1 0.614 99.3 94.8 0.005* 83.3 75.8 0.274 95.6 86.5 0.001*
  UAS800 65.2 60.4 0.797 52.1 63.2 0.027* 9.9 33.7 <0.001* 94.9 83.8 0.002*
  Cobas® u701 56.5 54.2 0.999 63.4 78.7 0.001* 11.1 44.1 <0.001* 94.7 84.7 0.002*
  iQ®200SPRINT 34.8 37.5 0.999 96.8 93.5 0.140 47.1 64.3 0.205 94.8 82.9 <0.001*
URiSCAN® PlusScope 26.1 29.2 0.999 98.6 96.1 0.177 60.0 82.9 0.440 94.3 81.4 <0.001*

*P-value < 0.05 represents statistical significance.
†WBC detection was considered positive if ≥ 10/μL was determined by each urine sediment analyzer.
‡The cut-off values for bacterial counts were predetermined by the manufacturers. For bacteria, the UF-1000i was also evaluated as a reference analyzer for comparison.
§Semi-quantitative results of ‘1+’, ‘2+’, and ‘3+’ were considered ‘positive’.
Abbreviations: PPV, positive predictive value; NPV, negative predictive value; M, male; F, female; LE, leukocyte esterase; WBC, white blood cell.