Ann Clin Microbiol 2021;24:83-96. Evaluation of Five Automated Urine Analyzers as Screening Instruments for Enhancing Diagnostic Efficiency in Urinary Tract Infection

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Table 4. Performance of each of indicator alone or in conjunction with other indicators in automated urine analyzers for the rapid diagnosis of urinary tract infection
Indicator Parameter Sensitivity (%) Specificity (%) PPV (%) NPV (%)
M F M F M F M F
Positive for Urine chemistry UF-5000 21.7 16.7 99.3 98.1 71.4 72.7 94.0 79.2
UAS800 26.1 14.6 99.3 97.4 75.0 63.6 94.3 78.6
Cobas® u701 30.4 16.7 96.1 95.5 38.9 53.3 94.5 78.7
iQ®200SPRINT 17.4 12.5 100.0 98.1 100.0 66.7 93.7 78.4
URiSCAN® PlusScope 17.4 10.4 100.0 98.7 100.0 71.4 93.7 78.1
Urine sediment* UF-5000 39.1 41.7 99.3 96.8 81.8 80.0 95.3 84.3
UAS800 43.5 27.1 89.4 87.1 25.0 39.4 95.1 79.4
Cobas® u701 43.5 31.3 93.0 91.6 33.3 53.6 95.3 81.1
iQ®200SPRINT 34.8 27.1 95.8 97.4 40.0 76.5 94.8 81.2
URiSCAN® PlusScope 26.1 16.7 100.0 96.8 100.0 61.5 94.4 78.9
Urine sediment† UF-5000 21.7 10.4 99.6 98.7 83.3 71.4 94.0 78.1
UAS800 13.0 6.3 99.6 99.4 75.0 75.0 93.4 77.4
Cobas® u701 8.7 6.3 100.0 99.4 100.0 75.0 93.1 77.4
iQ®200SPRINT 21.7 – 99.6 – 83.3 – 94.0 –
URiSCAN® PlusScope 13.0 16.7 100.0 96.8 100.0 61.5 93.4 78.9
Both (chemistry & sediment)* UF-5000 21.7 14.6 99.6 98.7 83.3 77.8 94.0 78.9
UAS800 21.7 6.3 99.6 100.0 83.3 100.0 94.0 77.5
Cobas® u701 26.1 12.5 98.9 98.1 66.7 66.7 94.3 78.4
iQ®200SPRINT 13.0 6.3 100.0 99.4 100.0 75.0 93.4 77.4
URiSCAN® PlusScope 17.4 8.3 100.0 98.7 100.0 66.7 93.7 77.7
Both (chemistry & sediment)† UF-5000 8.7 8.3 100.0 98.7 100.0 66.7 93.7 77.7
UAS800 – 2.1 – 100.0 – 100.0 – 76.7
Cobas® u701 4.3 4.2 100.0 99.4 100.0 66.7 92.8 77.0
iQ®200SPRINT 8.7 – 100.0 – 100.0 – 93.1 –
URiSCAN® PlusScope 8.7 8.3 100.0 98.7 100.0 66.7 93.1 77.7
Negative for Urine chemistry UF-5000 56.5 56.3 69.4 58.1 13.0 29.3 95.2 81.1
UAS800 52.2 50.0 69.0 58.7 12.0 27.3 94.7 79.1
Cobas® u701 52.2 58.3 65.5 56.8 10.9 29.5 94.4 81.5
iQ®200SPRINT 43.5 54.2 71.5 61.3 11.0 30.2 94.0 81.2
URiSCAN® PlusScope 39.1 47.9 73.6 67.1 10.7 31.1 93.7 80.6
Urine sediment* UF-5000 65.2 60.4 81.3 92.9 22.1 72.5 96.7 88.3
UAS800 78.3 33.3 46.8 95.5 10.7 69.6 96.4 82.2
Cobas® u701 69.6 56.3 54.9 78.1 11.1 44.3 95.7 85.2
iQ®200SPRINT 65.2 14.6 70.8 98.1 15.3 70.0 96.2 78.8
URiSCAN® PlusScope 43.5 50.0 91.9 85.2 30.3 51.1 95.3 84.6
Urine sediment‡ UF-5000 100.0 100.0 8.5 2.6 8.1 24.1 100.0 100.0
UAS800 95.7 93.8 1.8 1.9 7.3 22.8 93.3 83.3
Cobas® u701 82.6 25.2 23.6 21.3 8.1 25.2 94.4 82.5
iQ®200SPRINT 95.7 31.6 4.6 41.3 7.5 31.6 92.9 91.4
URiSCAN® PlusScope 69.6 26.1 56.0 45.2 11.3 26.1 95.8 79.5
Both (chemistry & sediment)* UF-5000 39.1 77.1 98.9 47.1 75.0 31.1 95.3 86.9
UAS800 47.8 79.2 89.1 37.4 26.2 28.1 95.5 85.3
Cobas® u701 47.8 75.0 90.1 40.0 28.2 27.9 95.5 83.8
iQ®200SPRINT 39.1 72.9 95.8 42.6 42.9 28.2 95.1 83.5
URiSCAN® PlusScope 26.1 68.8 100.0 60.6 100.0 35.1 94.4 86.2
Both (chemistry & sediment)‡ UF-5000 91.3 95.8 37.7 19.4 10.6 26.9 98.2 93.8
UAS800 78.3 70.8 52.8 45.2 11.8 28.6 96.8 83.3
Cobas® u701 60.9 50.0 72.2 80.6 15.1 44.4 95.8 83.9
iQ®200SPRINT 78.3 12.5 41.2 98.1 9.7 66.7 95.9 78.4
URiSCAN® PlusScope 26.1 10.4 99.3 98.7 75.0 71.4 94.3 78.1

*Diagnostic performances were calculated by applying the cut-off values set by each manufacturer without any adjustments.
†A cut-off value that met 70% of PPV was used for estimating the number of samples that were highly likely to be positive and would justify empiric antibiotic treatment.
‡A cut-off value that met 95% of sensitivity was used for estimating the number of samples that were highly likely to be negative and did not need further culture.
Abbreviations: PPV, positive predictive value; NPV, negative predictive value; M, male; F, female.