Ann Clin Microbiol 2021;24:97-104. Fecal Microbiota Transplantation against Gut Colonization Using a Multidrug-Resistant Organism

Table 1. SIGN criteria for assignment of levels of evidence
Level Description
1++ High quality meta-analyses, systematic reviews of RCTs, or RCT with a very low risk of bias
1+ Well-conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias
1- Meta-analyses, systematic reviews, or RCTs with a high risk of bias
2++ High quality systematic reviews of case control or cohort studies
2+ High-quality case-control or cohort studies with a very low risk of confounding or bias and a high probability that the relationship is causal
2- Well-conducted case-control or cohort studies with a low risk of confounding or bias and a moderate probability that the relationship is causal
3 Case-control or cohort studies with a high risk of confounding or bias and a significant risk that the relationship is not causal
4 Expert opinion

Abbreviatons: SIGN, Scottish intercollegiate guideline network; RCT, randomized controlled trial.