Ann Clin Microbiol 2022;25:25-29. Analysis of neutralization antibodies in patients with mild COVID-19 infection after 100 days using microneutralization test
Table 1. Clinical characteristics, differences in Ct values and ELISA OD between neutralizing antibody-positive and -negative patients measured by microneutralization
Characteristic Neutralizing antibody P-value
Positive (n = 9) No. (%) Negative (n = 21) No. (%) Total (n = 30) No. (%)
Sex, male 5 (55.6) 8 (38.1) 13 (43.3) 0.630
Age (yr)* 53.4 ± 9.9 40.8 ± 14.4 44.6 ± 14.3 0.033
Presentation of COVID-19
NEWS score at admission 1 [0–1.5] 0 [0–1.5] 1 [0–1.25] 0.504
Pneumonia 8 (88.9) 8 (38.1) 16 (53.3) 0.017
Oxygen support via nasal prong 1 (11.1) 0 1 (3.3) 0.300
Asymptomatic patients 0 3 (14.3) 3 (10.0) 0.530
Interval of diagnosis and sample collection(days)* 112.7 ± 15.9 116.4 ± 14.5 115.3 ± 14.8 0.525
Ct value
E 19.3 [18.8–19.6] 27.4 [22.4–30.1] 23.2 [19.3–28.6] 0.005
RdRp 17.9 [16.9–20.0] 27.9 [23.5–32.0] 24.6 [17.9–29.8] 0.003
N 20.7 [19.4–22.2] 24.0 [19.6–30.5] 21.8 [19.6–24.0] 0.236
Neutralizing antibody reciprocal titer 80 [80–160] 20 [10–40] 40 [20–80]
ELISA OD 0.89 [0.63–0.92] 0.35 [0.26–0.45] 0.44 [0.28–0.67] 0.002