Ann Clin Microbiol 2022;25:119-124. Predicting phenotypic antimicrobial resistance in Escherichia coli isolates, using whole genome sequencing data
Table 1. Concordance rates between phenotypic antimicrobial susceptibility and genotype with the presence of resistance genes or mutation
Concordance rates: % (n/n)*
GM-R CP-RSXT-RTET-RCIP-R
aac(3′)-IIa: 100 (1/1)catA1: 100% (2/2) sul only: 3 (1/35)tet(A): 99 (82/83)parC: 50 (1/2)
aac(3)-IId: 100 (2/2)catB3: 100% (3/3) sul2: 0 (0/32)tet(A)+tet(B): 100 (1/1)qnrB19: 100 (2/2)
aac(3)-IId+aadA2: 67 (2/3)sul3: 50 (1/2)qnrS1: 0 (0/3)
aac(3)-IId+aadA5: 100 (1/1)sul1+sul2: 0 (0/1)qnrS2: 100 (1/1)
aac(3)-IIe: 50 (1/2)dfr only: 33 (1/3)qnrS2+aac(6′)Ib-cr: 100 (3/3)
aac(3)-Iva+aadA1+aadA2dfrA12: 50 (1/2)aac(6′)Ib-cr: 0 (0/1)
+aph(4)-Ia: 100 (1/1)dfrA14: 0 (0/1)
aac(3)-Iva+aadA2+aph(4)-Ia; 33 (1/3)sul+dfr: 88 (29/33)
aac(3)-Iva+aph(4)-Iva: 27 (4/15)sul1+dfrA17: 100 (1/1)
aac(3)-VIa+aadA1:100 (1/1)sul2+dfrA1: 100 (1/1)
aac(6′)Ib-cr: 0 (0/1)sul2+dfrA12: 100 (1/1)
aac(6′)Ib-cr+aadA5: 0 (0/3)sul2+dfrA14: 100 (5/5)
aadA1: 0 (0/3)sul2+dfrA17: 100 (5/5)
aadA1+aadA5: 0 (0/1)sul3+dfrA17: 100 (1/1)
aadA2: 14 (1/7)sul1+sul2+dfrA12: 75 (9/12)
aadA5: 0 (0/7)sul1+sul2+dfrA14+drfA17: 50 (1/2)
aadA5+aph(3′)-Ia: 0 (0/1)sul1+sul2+dfrA17: 100 (5/5)
aadA12: 0 (0/2)
aph(3′)-Ia: 0 (0/1)

*The number of isolates with phenotypical resistance/the number of isolates with resistance genes or mutations. TET-R tet(A): 99 (82/83) tet(A)+tet(B): 100 (1/1) CIP-R parC: 50 (1/2) qnrB19: 100 (2/2) qnrS1: 0 (0/3) qnrS2: 100 (1/1) qnrS2+aac(6′)Ib-cr: 100 (3/3) aac(6′)Ib-cr: 0 (0/1) Abbreviations: GM-R, phenotypic resistance to gentamicin; CP-R, phenotypic resistance to chrolamphenicol; SXT-R, phenotypic resistance to trimethoprimsulfamethoxazole; TET-R, phenotypic resistance to tetracycline; CIP-R, phenotypic resistance to ciprofloxacin.