Ann Clin Microbiol 2024;27(4):245-255. Current nonculture-based diagnosis of candidemia
| General target | Function | Available commercial kit | Overall sensitivity (95% CI) | Overall specificity (95% CI) | Reference |
|---|---|---|---|---|---|
| Candida (1,3)-β-D-glucan | Candida Cell wall component | Fungitell; Wako; Fungitec-G; Dynamiker Fungus | 0.81 (0.75-0.86) | 0.64 (0.55-0.71) | [11] |
| Candida mannan | Candida Cell wall component | Platelia Candida Ag-Plus and Ab-Plus; Serion Mannan kit | 0.58 (0.53-0.62) | 0.93 (0.91-0.94) | [22] |
| Anti-mannan antibody | Antibodies to Candida polysaccharides | Platelia Candida Ab-Plus | 0.59 (0.54-0.65) | 0.83 (0.79-0.87) | [22] |
| C. albicans germ tube antibody (CAGTA) | Antibodies to Candida protein extract | Invasive Candidasis (CAGTA) IFA IgG assays; VirClia IgG Monotest | 0.66 (0.59-0.73) | 0.76 (0.58-0.88) | [32] |
Abbreviation: CI, confidence interval.