Ann Clin Microbiol 2022;25:41-46. Antiviral resistance in human cytomegalovirus due to UL54 mutations without UL97 mutations
Table 1. Human cytomegalovirus UL97/UL54 gene mutations observed in this study
Case No.YearUL97 mutations (specimen)UL54 mutations (specimen)Viral loads
32019A594P (blood)4.12 log IU/mL
62018F412L (blood)3.03 log IU/mL
72018L595F (blood)N408D (blood)4.40 log copies/mL
112017V715M (blood)3.34 log copies/mL (blood)
142018L501I (CSF)4.73 log copies/mL (CSF)
192017L802M (CSF)5.92 log copies/mL
222017505-506 in frame deletion (anterior chamber fluid)V787L (blood)4.72 log copies/mL
292017C603W (blood)N/A
322016C603W (blood)N408D/P522S (blood)3.57 log copies/mL
402016M460V (blood)5.69 log copies/mL
462015A594V (blood)4.12 log copies/mL
552015597-600 in frame deletion (blood)2.42 log copies/mL
602014L595S (blood)2.42 log copies/mL
652013M460I (blood)4.59 log copies/mL
402019M460V (blood)3.99 log IU/mL
462015A594V (blood)2.42 log copies/mL
552014597-600 in frame deletion (blood)2.42 log copies/mL
602013L595S (blood)4.59 log copies/mL
652019M460I (blood)3.99 log IU/mL
Abbreviations: CSF, cerebrospinal fluid; N/A, not available.