Fig. 4. Putative identification of other streptococcal ICEs resembling Streptococcus uberis ICEs (UB37/UB68/UB23/UB99) with the S. uberis NZ01 reference genome. Similar or identical products between reference and candidate genomes are indicated by matching colors. Black gradations between corresponding genes indicate percent identity. A similar streptococcal ICE was identified in Streptococcus suis strain STC78 (ICEnsui78–tet(O)–erm(B); accession number ON944185), based on conserved product arrangements between UB37/UB68/UB23/UB99 ICEs and ICEnsui78. Core products are in red font, and antimicrobial resistance products are in blue font. ICEUB37 was re-annotated using the Prokaryotic Genomes Annotation Pipeline, and ICE components were identified using ICEscreen. Protein function similarities were inferred using Basic Local Alignment Search Tool x, with the predicted protein functions shown in brackets. Figure is cited from [45]. WGS, whole-genome sequencing; ICE, integrative and conjugative element.