Original article Ung-Jun Kim1, Choon-Mee Kim2, Sook-Jin Jang1, Seul-Bi Lee1, Seong-Sik Cho1, Seok-Hoon Jeong3, Young-Jin Ko1, Seong-Ho Kang1, Geon Park1, Dong-Min Kim4, Na-Ra Yoon4, Young-Joon Ahn5, Dong-hoon Lim6, Joong-Ki Kook7 1Department of Tropical Medicine and Parasitology, Seoul National University College of Medicine, Seoul2Department of Parasitology and Tropical Medicine, Gyeongsang National University College of Medicine, Jinju;3MediCheck Research Institute, Korea Association of Health Promotion, Seoul, Korea Corresponding to Sook-Jin Jang, E-mail: sjbjang@chosun.ac.kr Ann Clin Microbiol 2020;23(1):11-20. https://doi.org/10.5145/ACM.2020.23.1.11Received on 29 May 2019, Revised on 11 September 2019, Accepted on 11 September 2019, Published on 20 June 2024.Copyright © Korean Society of Clinical Microbiology. Abstract Background: Acinetobacter baumannii infection is a significant health problem worldwide due to increased drug resistance. The limited antimicrobial alternatives for the treatment of severe infections by multidrug-resistant A. baumannii (MDRAB) make the search for other therapeutic options more urgent. Linalool, the major oil compound in Coriandrum sativum, was recently

Original article PDF Geon Park, M.D.1, Sook-Jin Jang, M.D.1,2, Ho-Jong Jeon, M.D.3, Seong-Hwan Kim, M.D.4, Mi-Ja Lee, M.D.3, Jin-Hee Kim, M.S.1, Sung-Heui Shin, M.D.2, Bidur Prasad Chaulagain, M.S.1,2, Dong-Min Kim, M.D.5, Dae-Soo Moon, M.D.1, Young-Jin Park, M.D.1 Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea Corresponding to Sook Jin Jang, E-mail: sjbjang@chosun.ac.kr Ann Clin Microbiol 2007;10(2):84-89.Copyright © Korean Society of Clinical Microbiology. Abstract Background: In hepatocellular carcinoma (HCC), the frequency of p53 mutation and the association with hepatitis B virus (HBV) infection varies with geographic locations and risk factors. The aim of this study was to determine the frequency of codon 249 mutation of p53, p53 overexpression, and HBV DNA positivity and to observe the relationship between them in Korean HCC. Methods: We analyzed overexpression of p53 in hepatoma tissue from 17 HCC patients by immunohistochemistry (IHC), specific mutations at the third base position of

Original article PDF Choon-Mee Kim1*, In Sun Choi2*, Sook Jin Jang2, Na-Ra Yun3, Dong-Min Kim3, Donghoon Lim4, Young-Joon Ahn5, Seong Ho Kang2, Geon Park2, Dae Soo Moon2 1Premedical Science, College of Medicine, Chosun University, Departments of 2Laboratory Medicine, 3Internal Medicine, 4Urology, 5Medical Education, College of Medicine, Chosun University, Gwangju, Korea Corresponding to Sook Jin Jang, E-mail: sjbjang@chosun.ac.kr Ann Clin Microbiol 2017;20(4):90-96. https://doi.org/10.5145/ACM.2017.20.4.90Copyright © Korean Society of Clinical Microbiology. Abstract Background: Tigecycline resistance has emerged recently and has shown diverse mechanisms. The aim of this study was to assess the role of efflux activity in tigecycline resistance in 120 clinical isolates of A. baumannii using two methods: the H33342 accumulation assay and adeB real-time reverse transcriptase polymerase chain reaction. In addition, we analyzed the correlation between the expression level of adeB and H33342 accumulation level. Methods: A. baumannii clinical isolates was divided into tigecycline-resistant (49 strains), intermediate (40 strains), and susceptible (31 strains) groups. The H33342 accumulation was measured in the absence or