Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology

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Weeks in Review

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Weeks to Publication
Indexed in KCI, KoreaMed, Synapse, DOAJ
Open Access, Peer Reviewed
pISSN 2288-0585 eISSN 2288-6850

Search Results for: Jong Hee Shin

Fungal infections: rising threats, diagnostic challenges, and the path forward for clinical microbiology laboratories

Editorial Jayoung Kim Department of Laboratory Medicine, International St. Mary’s Hospital, College of Medicine, Catholic Kwandong University, Incheon, Korea Corresponding to Jayoung Kim, E-mail: lmkjy7@gmail.com Ann Clin Microbiol 2024;27(4):217-219. https://doi.org/10.5145/ACM.2024.27.4.1Received on 17 December 2024, Revised on 19 December 2024, Accepted on 19 December 2024, Published on 20 December 2024.Copyright © Korean Society of Clinical Microbiology.This is an Open Access article which is freely available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/). Fungal diseases are becoming a growing global health concern, with an estimated annual incidence of 6.5 million cases of invasive fungal infections and approximately 3.8 million associated deaths, including approximately 2.5 million directly attributable to fungal infections [1]. The World Health Organization, in its first fungal priority pathogen list, identified 19 major fungal pathogens posing considerable public health threats, with Candida albicans, Candida auris, and Cryptococcus neoformans classified as critical fungal pathogens [2]. Moreover, since

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Candida and candidemia in Korea

Review article Yong Jun Kwon, Jong Hee Shin Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea Corresponding to Jong Hee Shin, E-mail: shinjh@chonnam.ac.kr Ann Clin Microbiol 2024;27(4):231-244. https://doi.org/10.5145/ACM.2024.27.4.3Received on 9 October 2024, Revised on 27 November 2024, Accepted on 29 November 2024, Published on 20 December 2024.Copyright © Korean Society of Clinical Microbiology.This is an Open Access article which is freely available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/). Abstract Purpose: Candidemia is a common cause of nosocomial bloodstream infections associated with high mortality rates. Its incidence varies significantly across countries and hospitals, and its epidemiology is a subject of continuous investigation. This review aims to provide a comprehensive analysis of candidemia in Korea, addressing its changing epidemiology, species distribution, antifungal resistance, and clinical implications. Current content: In Korea, Candida albicans remains the most common isolate in blood cultures; however, infections caused by

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Four genotypes of carbapenem-resistant Acinetobacter baumannii strains lacking OXA-23 production in Korea

Brief communication Young Ah Kim1, Seok Hoon Jeong2,3, Jong Hee Shin4, Kyeong Seob Shin5, Jeong Hwan Shin6, Young Ree Kim7, Hyun Soo Kim8, Young Uh9, Nam Hee Ryoo10 1Department of Laboratory Medicine, National Health Insurance Service Ilsan Hospital, Goyang, 2Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, 3Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, 4Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, 5Department of Laboratory Medicine, Chungbuk National University College of Medicine, Cheongju, 6Department of Laboratory Medicine and Paik Institute for Clinical Research, Inje University College of Medicine, Busan, 7Department of Laboratory Medicine, Jeju National University, College of Medicine, Jeju, 8Department of Laboratory Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, 9Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju, 10Department of Laboratory Medicine, Keimyung University School of Medicine, Daegu, Korea Corresponding to Young Ah

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Laboratory Diagnosis of Opportunistic Fungal Infections

Review article PDF Jong Hee Shin, M.D. Department of Clinical Pathology, Chonnam University Medical School, Kwangju, Korea Corresponding to Jong Hee Shin Ann Clin Microbiol 1998;1(1):37-43.Copyright © Korean Society of Clinical Microbiology. Abstract In the past decades there has been a dramatic increase in the number of opportunistic fungal infections. Establishing the diagnosis of opportunistic fungal infections in compromised patients is not simple. The laboratory diagnostic tests include microscopic examination, culture and serological tests. Although the most reliable method is the histologic examination, various opportunistic fungal agents can reveal similar histologic morphology. Culture should be attempted, however, the isolation of these organisms from cultures must be interpretated with caution, because the causing agents for opportunistic fungal infections are common laboratory contaminants. Serology for fungal infections has limited value except cryptococcal antigen: the usefulness of detection of antigenemia in invasive candidiasis and invasive aspergillosis has been limited by the rapid clearance

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A Case of Infective Endocarditis Caused by Haemophilus paraphrophilus

Case report PDF Myoung Youn, M.D., Jong Hee Shin, M.D., Soon Pal Suh, M.D. and Dong Wook Ryang, M.D. Department of Clinical Pathology, Chonnam University Medical School, Kwangju, Korea Corresponding to Jong Hee Shin, E-mail: shinjh@chonnam.chonnam.ac.kr Ann Clin Microbiol 1999;2(1):95-100.Copyright © Korean Society of Clinical Microbiology. Abstract Haemophilus paraphrophilus is a normal inhabitant of the naso- and oropharynx and has been rarely reported as a cause of endocarditis. H. paraphrophilus is a slow-growing and fastidious gram-negative bacterium and belongs to the HACEK group. We experienced a case of infective endocarditis due to H. paraphrophilus. The organism was repeatedly isolated from the blood cultures of a 60 year-old patient presenting with high fever, chills, cardiac murmur, and change of mental state. The patient had a history of mitral and tricuspid valve replacements and had been followed up for complications of cirrhosis of liver such as esophageal varix and oral bleeding. The isolate was identified as H.

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Clinical Characteristics of Pediatric Patients with Candidemia

Original article PDF Kung Ok Yoo, M.D.*, Sang Khoo Lee, M.D.***, Chang Jae Lee, M.D.*, Jong Hee Shin, M.D.*,**, Soon Pal Suh, M.D.*,** and Dong Wook Ryang, M.D.*,** Department of Clinical Pathology*, Chonnam National University Medical School, Research Institute of Medical Sciences**, Chonnam National University, Gwangju, Korea and Mokpo Catholic Hospital,*** Mokpo, Korea Corresponding to Jong Hee Shin, E-mail: shinjh@chonnam.ac.kr Ann Clin Microbiol 2001;4(2):122-128.Copyright © Korean Society of Clinical Microbiology. Abstract Background:The incidence of candidemia in paediatric patients has increased over the last decade. We analysed the clinical characteristics of pediatric patients with candidemia over a 3-year period in Chonnam National University Hospital. Methods:The medical records of 28 patients with candidemia diagnosed between 1996 and 1998 were retrospectively reviewed. Clinical characteristics including underlying illness, risk factors, therapy and outcome were assessed in relation to causing Candida species. Results:The causing agents were mainly non-C. albicans species (24/28 cases, 81.5%). Underlying illnesses

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Evaluation of a Polymerase Chain Reaction Assay and BACTEC Culture for the Detection of Mycobacterium tuberculosis in Clinical Specimens

Original article PDF Chang Jae Lee, M.D.*, Seung Jung Kee, M.D.*, Jong Hee Shin, M.D.*,**, Soon Pal Suh, M.D.*,** and Dong Wook Ryang, M.D.*,** Department of Clinical Pathology*, Chonnam National University Medical School; Research Institute of Medical Sciences**, Chonnam National University, Gwangju, Korea Corresponding to Soon Pal Suh, E-mail: spsuh@chonnam.ac.kr Ann Clin Microbiol 2001;4(2):115-121.Copyright © Korean Society of Clinical Microbiology. Abstract Background: The PCR assay for the detection of M. tuberculosis has been used for 5 years in Chonnam National University Hospital. To evaluate the reliability of the PCR assay, the PCR results were compared with those of culture and clinical diagnosis. Methods : This study analyzed the results of BACTEC culture and PCR for detection of M. tuberculosis between Jan. 1996 and Dec. 1998. A total of 7,430 specimens for the PCR, 16,163 specimens for the TB BACTEC culture and 4,810 specimens (3,167 patients) submitted for both PCR and BACTEC culture were analyzed

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Random Amplified Polymorphic DNA (RAPD) Analysis for Aspergillus Species Isolated from Clinical Specimens

Original article PDF Jong Hee Shin, M.D., Chang Jae Lee, M.D., Jee Yeon Lee, M.D., Jeong Won Song, M.D., Seong Jung Kee, M.D., Soon Pal Suh, M.D., and Dong Wook Ryang, M.D. Department of Clinical Pathology, Chonnam National University Medical School, Kwangju, Korea Corresponding to Jong Hee Shin, E-mail: shinjh@chonnam.ac.kr Ann Clin Microbiol 2001;4(1):33-39.Copyright © Korean Society of Clinical Microbiology. Abstract Background : Aspergillus species are second only to Candida species as the most commonly isolated fungi from clinical specimens. As well as the identification of the Aspergillus species, it has been necessary for epidemiological studies to differentiate between strains of the same species. We performed genotypic identification and characterization of species and strains within the genus Aspergillus by using RAPD. Methods : A total of 63 clinical strains of Aspergillus species (including 21 A. fumigatus, 12 A. flavus, 12 A. niger, 12 A. terreus, 3 A. nidulans, and 3 A. sydowii) from 63 patients was analyzed. For RAPD alanysis, M13 primer (5’GAGGGTGGCGGTTCT3’) and five random 10-mer

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Current Status of Antifungal Suscepitibility Testing: Technical Advances and Clinical Applications

Review article PDF Jong Hee Shin Department of Laboratory Medicine, Chonnam National University Medical School, Gwanju, Korea Corresponding to Jong Hee Shin, E-mail: shinjh@chonnam.ac.kr Ann Clin Microbiol 2002;5(2):69-76.Copyright © Korean Society of Clinical Microbiology. Abstract 최근 진균에 의한 중증감염의 빈도가 증가함에 따라 항진균제 감수성 검사의 필요성이 제기되었다[1-3]. 전신적 진균감염의 치료에는 오랫동안 amphotericin B와 flucytosine만이 사용되어 왔으나 근래에는 itraconazole, ketoconazole 및 fluconazole 등 이외에도 새로운 triazoles (voriconazole, ravuconazole 및 posaconazole)과 echinocandin제제(caspofungin, anidulafungin 및 micafungin) 등 다양한 항진균제가 개발되어 생체외 감수성검사를 통해 선택이 가능해졌다[3]. 또 후천성면역결핍증 환자에서 발생한 재발성 구인두 칸디다증(oropharyngeal candidiasis)의 치료를 위해 fluconazole을 장기 투여한 경우 fluconazole 내성 Candida albicans가 출현했다고 보고[4, 5]됨에 따라 항진균제 내성의 검출도 필요해졌다. 따라서 항진균제 감수성 검사는 최근 큰 진전을 보이고 있다[6-11]. (Korean J Clin Microbiol 2002;5(2):69-76)

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Prevalence & Diversity of Extended-spectrum β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Isolates in Korea

Original article PDF Seong Geun Hong1, Sunjoo Kim2, Seok Hoon Jeong3, Chulhun L. Chang4, Sung Ran Cho5, Ji Young Ahn5, Jong Hee Shin6, Hye Soo Lee7, Won Keun Song8, Young Uh9, Jong Hwa Yum10, Dongeun Yong10, Kyungwon Lee10, Yunsop Chong10 Department of Laboratory Medicine, Coll. of Med., Pochon CHA Univ.1, Gyeongsang Nat. Univ. School of Med.2, Coll. of Med. Kosin Univ.3, Pusan Nat. Univ. Coll. of Med.4, Sooncheonhyang Univ. Coll. of Med.5, Chonnam Nat. Univ. Med. School6, Chonbuk Univ. Med. School7, Hanllym Univ. Coll. of Med.8, Yonsei Univ. Wonju Coll. of Med.9, Yonsei Univ. Coll. of Med.10 Corresponding to Kyungwon Lee, E-mail: leekcp@yumc.yonsei.ac.kr Ann Clin Microbiol 2003;6(2):149-155.Copyright © Korean Society of Clinical Microbiology. Abstract Background:Increase in extended-spectrum β-lactamase(ESBL)-producing Escherichia coli and Klebsiella pneumoniae have been reported in Korea. The aim of this study was to determine the nationwide prevalence of ESBL-producing E. coli and K. pneumoniae, and to investigate the types of ESBLs. Methods:A total of 2,221 E. coli and

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