Differences in Antimicrobial Resistance Phenotypes by the Group of CTX-M Extended-Spectrum β-Lactamase

바름 권¹² 은정 윤^*2 도균 김² 혁민 이² 종희 신³ 정환 신⁴ 경섭 신⁵ 영아 김⁶ 영 어⁷ 영리 김⁹ 현수 김⁸ 석훈 정²

¹ Department of Clinical Pathology, Sangji University College of Science, Wonju
² Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul
³ Department of Laboratory Medicine, Chonnam National University School of Medicine, Gwangju
⁴ Department of Laboratory Medicine, Inje University Busan Paik Hospital, Busan,
⁵ Department of Laboratory Medicine,College of Medicine, Chungbuk National University, Cheongju,
⁶ Department of Laboratory Medicine, National Health Insurance Service Ilsan Hospital, Goyang
⁷ Department of Laboratory Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju
⁸ Department of Laboratory Medicine,Hallym University College of Medicine, Hwaseong
⁹ Department of Laboratory Medicine, School of Medicine,Jeju National University, Jeju,

* Corresponding author: Tel: +82-2-2019-3783, Fax: +82-2-2019-3784, E-mail: ejyoon@yuhs.ac

Keywords

CTX-M Escherichia coli Extended-spectrum β-lactamase Klebsiellapneumoniae

Acknowledgements

This research was supported by a fund (2017E4400100#) from the Research Program of Korea Centers for Disease Control and Prevention.

Figures & Tables

Fig. 1. Zone diameter of the four drugs (A and C) and the synergy with clavulanic acid (SC) (B and D) by bacterial species (A and B) and by groups of CTX-M (C and D). A total of 269 E. coli (ECO) and 76 K.pneumoniae (KPN) CTX-M producers (A and B) including 211 group 1 CTX-M producers and 123 group 9 CTX-M producers (C and D) were plotted. Boxplots present the 1 and 3 quartiles with whiskers showing either the maximum and minimum values. The thick horizontal line indicates median values, black lines for E. coli or group 1 CTX-M and gray lines for K.pneumoniae or group 9 CTX-M ESBL producers. The SC value was calculated by dividing the enlarged zone diameter near the CA disk by inhibition zone diameter of each drug. The statistical significance was calculated using Pearson’s chi-square test [16] by using SPSS statistics (version 23, IBM Corp., Armonk, NY, USA) and the significance (P) was indicated by using asterisks: **P<0.01; *P<0.05.