Genetic Variants and Haplotypes in the IL10 Gene and Their Association with Opportunistic Infections among HIV-Infected Patients in Korea in the Era of Highly Active Antiretroviral Therapy

인숙 김¹ 형호 김² 철훈 장^*1

¹ Department of Laboratory Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine
² Department of Laboratory Medicine and Biomedical Research Institute, Pusan National University Hospital,Pusan National University School of Medicine, Busan

* Corresponding author: Tel: +82-55-360-1870, Fax: +82-55-360-1880, E-mail: iskim0710@gmail.com

Keywords

Haplotype HIV IL10 Opportunistic infections Susceptibility

Acknowledgements

This paper was supported by Busan University’s Basic Science Research Program (two year).

Figures & Tables

Fig. 1. Linkage disequilibrium maps of the seven variants in all HIV-infected patients (A), HIV-infected patients with opportunistic infections (B), and HIV-infected patients without opportunistic infections (C). The pairwise D′ and r² values between pairs of adjacent markers were calculated with Haploview 4.2. The calculated pairwise D′ values of all diamonds were 1, which indicated complete linkage disequilibrium. The number in each diamond is the r² value, which is shown in a corresponding dark gray-to-white color gradient. Diamonds without a number indicate that the r² value was 1. No white colored diamonds are shown. Two haplotype tagging SNPs with rs1518111 and 3021094 distinguished each haplotype.