A Case Report of Saccharomyces cerevisiae Fungemia in a Premature Infant Following Probiotic Treatment

Jaewoong  Lee1   Hyunjung Kim1   Hae Kyung  Lee1*   Yeon-Joon  Park2   

1 Department of Laboratory Medicine, Uijeongbu St. Mary’s Hospital, Uijeongbu
2 Department of Laboratory Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul

Abstract

Probiotics are used to restore and maintain the healthy intestinal microflora. Although Saccharomyces cerevisiae (SC) is considered as a non-pathogenic yeast, administration of SC as a probiotic is associated with a rare cause of fungemia in immunocompromised patients with central venous catheter insertion. We encountered a case of SC fungemia in a premature infant who presented with respiratory distress syndrome and had undergone central venous catheterization.

Keywords

Central venous catheter   Fungemia   Premature birth   Probiotics   Saccharomyces cerevisiae   


Figures & Tables

Fig. 1. Microscopic image (A) and colony morphology (B) of Saccharomyces cerevisiae from the patient’s blood specimen.


Figures & Tables

Table 1. Test results of the two strains

TestStrain from the patientStrain from the Bioflor
API 20 C AUX (%)*Saccharomyces cerevisiae 2 (99)Saccharomyces cerevisiae 2 (99)
Vitek 2 Yeast ID (%)*Saccharomyces cerevisiae (95)Saccharomyces cerevisiae (95)
26s rRNA Sequencing Identities (%, Match/Total)†Saccharomyces cerevisiae (99, 1322/1323)Saccharomyces cerevisiae (99, 1322/1323)
Bruker Biotyper (Score)Saccharomyces cerevisiae (2.187)Saccharomyces cerevisiae (2.190)