Ann Clin Microbiol 2020;23:211-216. A Case of Prosthetic Valve Endocarditis with Cerebral Hemorrhage Caused by Rothia mucilaginosa
| Author | Year | Age/Sex | Risk factors | Pathogen | Antibiotic therapy | Intracranial complications | Outcome |
|---|---|---|---|---|---|---|---|
| Issacson et al. [Am J Med 1988; 84: 352-4] | 1988 | 27/F | Bicuspid aortic valve Periodontal abscess | R.dentocariosa | Penicillin + Gentamicin | Brain abscess | Cure (No sequelae) |
| Shands et al. [Am J Med 1988; 85: 280-1] | 1988 | 41/M | Mitral regurgitation | R.dentocariosa | Vancomycin + Gentamicin, then Penicilin + Gentamicin | Intracranial mycotic aneurysms with cerebral hemorrhage | Cure (No sequelae) |
| Binder et al. [Infection 1997; 25: 22-6] | 1997 | 70/M | Alcohol abuse Carious teeth Mitral regurgitation Aortic insufficiency | R.dentocariosa | Penicillin + Vancomycin + Netilmicin | Multiple brain abscesses, mitral insufficiency requiring reconstruction and replacement | Cure (No sequelae) |
| Binder et al. [Infection 1997; 25: 22-6] | 1997 | 50/M | Periodontiti s Prosthetic aortic valve | R.dentocariosa | Rifampin + Ceftriaxone | Aortic root abscess, intracerebral hemorrhage attributed to intracranial mycotic aneurysms | Unknown |
| Ricaurte et al. [South Med J 2001;9 4:438- 40] | 2001 | 49/M | Undefined heart murmur Dental work (root canal) | R.dentocariosa | Cefotaxime, then Vancomycin + Gentamicin | Right frontoparietal hematoma | Cure (No sequelae) |
| Boudewijns et al. [7] | 2002 | 17/F | Congenital bicuspid valve | R.dentocariosa | Penicillin + Amikacin | Intracranial mycotic aneurysms with subarachnoid hemorrhages, aortic root abscess requiring replacement | Death |
| Sadhu et al. [Diagn Microbiol Infect Dis 2005; 53: 239-40] | 2005 | 55/M | Diabetes mellitus Liver cirrhosis Dental abscess | R.dentocariosa | Penicillin + Gentamicin | Cerebellar hemorrhages | Cure (No sequelae) |
| Chowdhary et al. [Am J Med Sci 2015; 350: 239-40] | 2015 | 34/M | Intravenous drug user | R.dentocariosa | Vancomycin + Ceftriaxone + Doxycycline | Septic emboli to right middle cerebral artery | Cure (No sequelae) |
| Fridman et al. [Tex Heart Inst J 2016; 43: 255-7] | 2016 | 58/M | None | R.dentocariosa | Penicillin, then Vancomycin + Ceftazidime | Cerebral mycotic aneurysm, endogenous endopthalmitis | Cure (No sequelae) |
| Willner et al. [4] | 2018 | 62/F | None | R.dentocariosa | Vancomycin + Ceftriaxone, then Penicillin | Acute or subacute infarctions | Death |
| Tarumoto et al. [Intern Med 2012; 51: 3295-9] | 2012 | 40/M | None | R.aeria | Ceftriaxone + Gentamicin | hemorrhagic infarction with left posterior cerebral artery region | Cure (No sequelae) |
| Hiraiwa et al. [Eur J Intern Med 2013; 24 Suppl 1: e204] | 2013 | 63/M | Kidney transplantation Dental caries | R.aeria | Penicillin | Brain septic emboli | Cure (No sequelae) |
| Thiyagarajan et al. [BMJ Case Rep 2013. Doi: 10.113 6/bcr-2013-200534] | 2013 | 61/M | Tooth extraction | R.aeria | Penicillin + Rifampicin + Gentamicin | Septic emboli in temporal artery | Cure (No sequelae) |
| Crowe et al. [Infection 2014; 42: 419-23] | 2013 | 48/M | None | R.aeria | Penicillin + Gentamicin, then Rifampicin + Ciprofloxacin | Brain septic emboli | Cure (No sequelae) |
| Collarino et al. [New Microbes New Infect 2016; 13: 40-2] | 2016 | 57/M | Severe mitral insufficiency | R.aeria | Amoxicillin + Gentamicin | Left frontal subarachnoid hemorrhage | Cure (No sequelae) |
| Pinsky et al. [J Clin Microbiol 1989; 27: 215-6] | 1989 | 35/M | Intravenous drug user | R.mucilaginosa | Vancomycin + Gentamicin | Left frontal lobe infarction | Cure (No sequelae) |