Ann Clin Microbiol 2025;29(2):8. Whole-genome characterization of two azithromycin-resistant Neisseria gonorrhoeae ST1600 isolates from Busan, South Korea
| Characteristics | Year of isolation | |
|---|---|---|
| 2018 | 2019 | |
| Area of isolation (city) | Busan | Busan |
| Antimicrobial susceptibility (MIC (µg/mL) and interpretation) | ||
| Azithromycin | 32, R | 32, R |
| Ciprofloxacin | 32, R | 16, R |
| Spectinomycin | 32, S | 16, S |
| Tetracycline | 2, R | 4, R |
| Penicillin G | 2, R | 2, R |
| Cefixime | 0.06, S | 0.03, S |
| Ceftriaxone | 0.06, S | 0.03, S |
| Resistance determinants | ||
| 23S rRNA | C2611T mutation (4 alleles) | C2611T mutation (4 alleles) |
| mtrR promoter | -35A deletion | -35A deletion |
| Epidemiology | ||
| NG-MAST | ST16190 | ST16190a) |
| MLST | ST1600 | ST1600 |
| penA genotype | 109.001 | 120.001 |
a)A169G single-nucleotide polymorphism in porB 9414 and an identical tbpB allele 831.
Abbreviations: MIC, minimum inhibitory concentration; R, resistant; S, susceptible; NG-MAST, Neisseria gonorrhoeae multi-antigen sequence typing; MLST, multilocus sequence typing.