Table 1
SIGN criteria for assignment of levels of evidence
Table 2. SIGN criteria for assignment of levels of grades of recommendation
1Division of Healthcare Technology Assessment Research, Korea
2Division for New Health Technology Assessment, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea
3Department of Laboratory Medicine Asan Medical Center University of Ulsan College of Medicine, Seoul, Korea
*Corresponding author: E-mail: blu0924@neca.re.kr
September 2021
The Annals of Clinical Microbiology 2021 24(3):97-104
Received Date: 20 April 2021
Revised Date: 5 June 2021
Accepted Date: 19 August 2021
DOI: 10.5145/ACM.2022.24.3.4
Citation
The Annals of Clinical Microbiology 2021 24(3):97-104
Received Date: 20 April 2021
Revised Date: 5 June 2021
Accepted Date: 19 August 2021
DOI: 10.5145/ACM.2022.24.3.4
Citation
ABSTRACT
Background: Fecal microbiota transplantation against gut colonization using a multidrug-resistant organism is a technique used to treat infections through normalizing the gut microbiota via fecal microbiota transplantation in patients with confirmed colonization by carbapenem-resistant Enterobacteriaceae (CRE) or vancomycin-resistant enterococci (VRE) based on a fecal culture test within the past one week. In this study, we aimed to determine the safety and effectiveness of this technique.
Methods: The safety and effectiveness were assessed via a systematic review. A literature search was conducted using five Korean databases, such as KoreaMed, and international databases, including Ovid-MEDLINE, Ovid-EMBASE, and Cochrane Library.
Results: Main results are described here. From the studies retrieved using the aforementioned search strategy, the remaining 581 studies were screened using the inclusion and exclusion criteria, resulting in the selection of nine studies for further consideration. In terms of safety, many studies reported deaths and adverse reactions associated with different causes. Fewer studies reported the rate of colonization; however, the effect of colony rate was inconsistent when compared to no treatment group. Additionally, none of the studies assessed the recurrence rate, a decrease in the prevalence of diseases related to infection by multidrug-resistant bacteria, and the quality of life.
Conclusion: Fecal bacterial colonization for the decolonization of intestinal multidrug-resistant bacteria was evaluated using a technique that requires further research as there is insufficient literature evidence to validate its safety and efficacy in treating infections through normalizing the intestinal flora of patients with confirmed colonization by CRE or VRE.
