Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology


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Molecular Strain Typing in Clinical Microbiology Laboratory

Review article

Annals of Clinical Microbiology (Ann Clin Microbiol) 1998 December Volume 1, Issue 1, pages 14.

Molecular Strain Typing in Clinical Microbiology Laboratory

Eui-Chong Kim, M.D.

Department of Clinical Pathology, Seoul National University College of Medicine Seoul, Korea


Several molecular techniques has been introduced recently for the differentiation of microbial isolates: plasmid profiles, restriction fragment length polymorphism of chromosomal DNA or plasmids, ribotyping, arbitrarily primed PCR, pulsed-field gel electrophoresis(PFGE), and phylogenetic analysis. Molecular strain typing became an essential tool for epidemiological investigation. And conventional serotyping or phage typing methods are so time-consuming and labor-intensive that molecular fingerprinting methods are used as a substitute. Clinical microbiology laboratory cannot help doing strain typing for infection prevention and control, and should make a good choice among them in respect of efficiency and cost effectiveness. (Korean J Clin Microbiol 1998;1(1):14)