Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology


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pISSN 2288-0585 eISSN 2288-6850

Antimicrobial Resistance and Serotypes in the Clinical Isolates of Group B Streptococci

Original article

Annals of Clinical Microbiology (Ann Clin Microbiol) 1999 June Volume 2, Issue 1, pages 64-70.

Antimicrobial Resistance and Serotypes in the Clinical Isolates of Group B Streptococci

Young Uh, M.D., In Ho Jang, M.D., Gyu Yel Hwang, M.D. and Kap Jun Yoon, M.D.

Department of Clinical Pathology, Yonsei University Wonju College of Medicine, Wonju, Korea


Background:This study is designed to provide data on the trend of resistance by year of isolation in the clinical isolates of group B streptococci(GBS) during recent eight years and to elucidate the relationship between serotypes and antimicrobial resistance patterns.

Methods:The minimal inhibitory concentrations (MIC) of seven antimicrobial agents and serotypes for 150 strains of GBS isolated from clinical specimens between 1990 and 1997 were investigated.

Results:The resistance rate of 150 clinical isolates of GBS were 20.0% to clindamycin, 16.0% to erythromycin, 4.0% to chloramphenicol, and 95.3% to tetracycline. None was resistant to penicillin, ceftriaxone, or vancomycin. Of the 24 isolates resistant to erythromycin, 20 (83.3%) were resistant to clindamycin. Resistance rates of erythromycin according to serotypes in decreasing order were 69.2% (V), 23.2% (III), and 3.5% (Ib). All serotypes Ia and II were susceptible to erythromycin and clindamycin.

Conclusions:Striking emergence of resistant strains to erythromycin and clindamycin in our clinical isolates of GBS was mainly due to sudden increase of serotype V and III which shows multi-drug resistance phenotype. (Korean J Clin Microbiol 1999;2:64~70)


Group B streptococci (GBS), Antimicrobial susceptibility, Erythromycin resistance, Clindamycin resistance, Serotype