Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology


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pISSN 2288-0585 eISSN 2288-6850

Diagnostic Utility of a Rapid ICT Tuberculosis Assay for the Diagnosis of Pulmonary Tuberculosis

Original article

Annals of Clinical Microbiology (Ann Clin Microbiol) 1999 December Volume 2, Issue 2, pages 167-171.

Diagnostic Utility of a Rapid ICT Tuberculosis Assay for the Diagnosis of Pulmonary Tuberculosis

Wonkeun Song, M.D., Jin Tae Suh, M.D.1, Jung-Oak Kang, M.D.2, Sun-E Kim, M.D.2, Myung Jae Park, M.D.3, Hee Chul Park, M.D.4, Yong Kyun Roh, M.D.5, and Dong Hun Shin, M.D.

Department of Clinical Pathology, Internal Medicine1, Thoracic and Cardiovascular Surgery2, and Family Medicine3, Hallym University College of Medicine; Department of Clinical Pathology, Kyung Hee University College of Medicine4; Department of Clinical Pathology, Hanyang University College of Medicine5, Seoul, Korea


Background: Diagnosis of tuberculosis is more complicated because of low sensitivity and time-consuming procedures of the conventional diagnostic methods as well as nonspecific clinical features. Recently the serologic diagnosis of tuberculosis has been reported as one of rapid sensitive and specific methods. We evaluated the ability of a rapid ICT Tuberculosis assay (AMRAD/ICT Diagnostics, Sydney, Australia) to detect pulmonary tuberculosis.

Methods: ICT Tuberculosis assay was performed to the sera from 50 patients with pulmonary tuberculosis (24 patients with smear positive, 26 patients with smear negative) and 105 controls (48 patients without tuberculosis, 57 healthy controls).

Results: Antibodies were detected in 22 of 24 (92%) smear positive patients and 22 of 26 (85%) smear negative patients who had been clinically diagnosed as having active pulmonary tuberculosis. Two (4.2%) out of 48 patients without tuberculosis and 1 (1.8%) out of 57 healthy controls had a positive antibody response. The overall sensitivity, specificity, and positive and negative predictive value of the ICT Tuberculosis assay were 88%, 97%, 94%, and 94%, respectively.

Conclusions: The ICT Tuberculosis assay was not only sensitive and specific but also rapid and simple. This assay will be useful as a diagnostic method of pulmonary tuberculosis in combination with sputum smear and X-ray. (Korean J Clin Microbiol 1999;2:167-171)


Pulmonary tuberculosis, ICT Tuberculosis assay, Antibody