Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology


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pISSN 2288-0585 eISSN 2288-6850

Clinical Characteristics of Pediatric Patients with Candidemia

Original article

Annals of Clinical Microbiology (Ann Clin Microbiol) 2001 December Volume 4, Issue 2, pages 122-128.

Clinical Characteristics of Pediatric Patients with Candidemia

Seungjun Lee1, Seong Chun Kim2, Sunjoo Kung Ok Yoo, M.D.*, Sang Khoo Lee, M.D.***, Chang Jae Lee, M.D.*, Jong Hee Shin, M.D.*,**, Soon Pal Suh, M.D.*,** and Dong Wook Ryang, M.D.*,** Kim1,3

Department of Clinical Pathology*, Chonnam National University Medical School, Research Institute of Medical Sciences**, Chonnam National University, Gwangju, Korea and Mokpo Catholic Hospital,*** Mokpo, Korea


Background:The incidence of candidemia in paediatric patients has increased over the last decade. We analysed the clinical characteristics of pediatric patients with candidemia over a 3-year period in Chonnam National University Hospital.

Methods:The medical records of 28 patients with candidemia diagnosed between 1996 and 1998 were retrospectively reviewed. Clinical characteristics including underlying illness, risk factors, therapy and outcome were assessed in relation to causing Candida species.

Results:The causing agents were mainly non-C. albicans species (24/28 cases, 81.5%). Underlying illnesses of patients were malignancy (n=12), surgical diseases (n=4), prematurity (n=2), and other medical illnesses of (n=10). Studies on clinical status at positive culture revealed antibiotic exposure (28/28, 100%), placement of central venous catheter (CVC, 16/28, 57.1%), use of total parenteral nutrition (15/28, 53.6%), and chemotherapy (14/28, 50%). Twenty patients were treated with amphotericin B and/or fluconazole and 15 patients’CVCs were removed. Overall mortality due to candidemia was 25%(7/28).

Conclusions:These data show that most of pediatric candidemia cases are caused by non-C. albicans species and associated with a relatively lower mortality rate. (Korean J Clin Microbiol 2001;4(2):122-128)


Candidemia, C. albicans, Central venous catheter, Pediatric patients