Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology


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Streptococcus pneumoniae Isolates with Decreased Susceptibility to Optochin

Case report

Annals of Clinical Microbiology (Ann Clin Microbiol) 2002 June Volume 5, Issue 1, pages 59-61.

Streptococcus pneumoniae Isolates with Decreased Susceptibility to Optochin

Seungok Lee, Jung-Joon Park, Eun-Jee Oh, Yeon-Joon Park, and Byung Kee Kim

Department of Clinical Pathology, Kangnam St. Marys Hospital, The Catholic University of Korea, Seoul, Korea


Streptococcus pneumoniae is the most common cause of community-acquired pneumonia in adults and an important agent in other infections, including meningitis, otitis media, and conjunctivitis, etc. The optochin susceptibility test is the most widely used method to discriminate S. pneumoniae from other streptococci. However, 0.8-1.5% of S. pneumoniae contain optochin resistant population. Recently, we experienced three cases of variants of S. pneumoniae with decreased susceptibility to optochin. Equivocal optochin disk test should be confirmed by bile solubility, agglutination test, or DNA probe test. (Korean J Clin Microbiol 2002;5(1):59-61)


Optochin, Decreased susceptibility, Streptococcus pneumoniae