Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology

6

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2

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Indexed in KCI, KoreaMed, Synapse, DOAJ
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pISSN 2288-0585 eISSN 2288-6850

A case of Small Colony Variants (SCVs) of Staphylococcus aureus from Sputum of a Patient with Chronic Renal Failure

Case report

Annals of Clinical Microbiology (Ann Clin Microbiol) 2003 December Volume 6, Issue 2, pages 164-167

A case of Small Colony Variants (SCVs) of Staphylococcus aureus from Sputum of a Patient with Chronic Renal Failure

Hye Soo Lee, Yong Kohn Cho, Dal Sik Kim, and Sam Im Choi

Department of Laboratory Medicine, Chonbuk National University Medical School and Institute for Medical Science, Jeonju, Koreae of Health Sciences, Gyeongsang National University College of Medicine, Jinju, Korea

Abstract

Recently, small colony variants (SCVs) of Staphylococcus aureus causing fatal infections are increasing, but rarely reported in Korea. S. aureus, SCVs are slow growing subpopulation that cause persistent and relapsing infections. S. aureus, SCVs are frequently auxotrophic for hemin, menadione, and CO2, and are often disrupted in their electron transport activity. With S. aureus, SCVs virulence is altered by a decrease in α-toxin production and susceptibility to various antibiotics, allowing their intracellular survival. We isolated S. aureus, SCVs from the sputum of a 67 year old male with pneumonia, chronic renal failure with hemodialysis and preventive antibiotic therapy. Because S. aureus, SCVs are easily missed or misdiagnosed as normal flora in routine culture due to their atypical growth behavior and biochemical reaction, the correct identification is very important, especially when no bacteria or unusual bacteria are found in patients with persistent or relapsing infections with long term antibiotic therapy. (Korean J Clin Microbiol 2003;6(2):164-167)

Keywords

S. aureus, Small colony variants, SCVs