Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology


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pISSN 2288-0585 eISSN 2288-6850

The Prevalence of Antimicrobial Resistance in Helicobacter pylori Isolated in Daejeon

Original article

Annals of Clinical Microbiology (Ann Clin Microbiol) 2005 June Volume 8, Issue 1, pages 47-50.

The Prevalence of Antimicrobial Resistance in Helicobacter pylori Isolated in Daejeon

Jongwook Lee1 *, Sun Moon Kim2, Euyi Hyeog Im2, Young Woo Choi2, Yoon Mee Kim3 , Pum Soo Kim4, and Jae Hag Lee5
Departments of Laboratory medicine1, Internal Medicine2, and Pathology3, Keonyang University Hospital, Daejeon; Department of Internal Medicine4, Inha University Hospital, Incheon; Department of Food and Nutrition5, Seoil College, Seoul, Korea


Background: The most commonly used regimen for the eradication of Helicobacter pylori is combination of a proton pump inhibitor, clarithromycin, and two other antibiotics, metronidazole and amoxicillin. The increase in resistance to antibiotics seems to result in a decrease in eradication efficacy for H. pylori. We investigated the prevalence of antibiotic resistance in H. pylori isolated in Daejeon area.

Methods: A total of 31 clinical isolates of H. pylori were collected from the patients who underwent upper gastrointestinal endoscopy in Keonyang University Hospital during the period from March to July 2004. Antibiotic susceptibility tests for metronidazole, amoxicillin, and clarithromycin were performed by the E test (AB Biodisk, Sweden) on an egg yolk medium containing triphenyltetrazolium. The resistance break points for amoxicillin, metronidazole, and clarithromycin were defined as 0.5 ㎍/mL, 8㎍/mL, 1 ㎍/mL, respectively.

Results: Resistance to amoxicillin, metronidazole, and clarithromycin was detected in 7.4% (2/ 27), 25.8% (8/31), 3.6% (1/28), respectively.

Conclusion: The resistance to amoxicillin and clarithromycin was uncommon in Daejeon area. (Korean J Clin Microbiol 2005;8(1):47-50)


Helicobacter pylori, Antimicrobial resistance, Amoxicillin, Metronidazole, Clarithromycin