Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology

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pISSN 2288-0585 eISSN 2288-6850

The First Outbreak of Shigellosis Caused by Shigella dysenteriae Type 8 in Korea

Original article

Annals of Clinical Microbiology (Ann Clin Microbiol) 2005 December Volume 8, Issue 2, pages 153-159.


https://doi.org/10.5145/ACM.2005.08.2.153

The First Outbreak of Shigellosis Caused by Shigella dysenteriae Type 8 in Korea

Junyoung Kim1 , Seonghan Kim1, Semi Jeon1, Yeonho Kang1, Duyoung Jeon2, Jungbeom Kim3, and Bokkwon Lee1
Laboratory of Enteric Infections, Department of Bacteriology, National Institute of Health, Korea Center for Disease Control and Prevention1; Laboratory of Microbiology, Jeollanamdo Institute of Health and Environment2; and Laboratory of Microbiology, Gyeonggido Institute of Health and Environment3, Korea

Abstract

Background: In May 2004, an outbreak of a diarrheal disease occurred among tourists returning from Mt. Geumgang in North Korea; Shigella dysenteriae type 8 was isolated from 12 of the 36 patients who were suffering from diarrhea. We investigated the genetic relatedness of the isolates.

Methods: The isolates were identified by VITEK system and serotyped by a slide agglutination test. Antimicrobial susceptibility was determined by the disk diffusion method and genetic relatedness was examined by pulsed-field gel electrophoresis (PFGE).

Results: All 12 isolates were identified as Shigella spp., and agglutinated by S. dysenteriae type 8 antisera. All of these isolates showed the same antibiotic susceptibility pattern, and were resistant to streptomycin, tetracycline and trimethoprim/sulfamethoxazole. PFGE patterns were classified into 2 types, sdx1 and sdx2, and the relatedness between these two types was 80.5%. Eleven isolates belonged to sdx1.

Conclusion: The antibiotic susceptibility pattern and genetic relatedness of the isolates strongly suggest that they were from the same origin. Because this is the first report of S. dysenteriae type 8 isolation in Korea, and all of these cases were related to foreign travel, the surveillance system and the ability of the clinical laboratory should be strengthened to prevent the entry and spread of rare and hitherto not reported infectious agents into Korea. (Korean J Clin Microbiol 2005;8(2):153-159)

Keywords

Shigella dysenteriae type 8, First outbreak, Antibiotic susceptibility, PFGE