Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology

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pISSN 2288-0585 eISSN 2288-6850

Two Cases of Vivax Malaria Recurred at 38 and 40 Days after Hydoxychloroquine Therapy

Case report

Annals of Clinical Microbiology (Ann Clin Microbiol) 2005 December Volume 8, Issue 2, pages 185-188.


https://doi.org/10.5145/ACM.2005.08.2.185

Two Cases of Vivax Malaria Recurred at 38 and 40 Days after Hydoxychloroquine Therapy

Chong-Rae Cho, Tae-Hyun Um, and Jae-Won Jeong1
Departments of Laboratory Medicine and Internal Medicine1, College of Medicine, Inje University, Ilsanpaik Hospital Goyang, Korea

Abstract

There are two stages in the life circle of Plasmodium spp in humans: exoerythrocytic and erythrocytic stages. Hydroxychloroquine is the major chemotherapeutic agent against malarial parasites in their erythrocytic stage. The recurrence of Plasmodium vivax malaria, which is usually caused by an inadequate treatment or the presence of drug resistant parasites, has been reported frequently in the world, but rarely in Korea. We experienced two patients who recurred with P. vivax malaria after hydroxychloroquine therapy, and treating with insufficient doses of the drug was suspected as the cause of the recurrence. (Korean J Clin Microbiol 2005;8(2):185-188)

Keywords

Plasmodium vivax, Inadequate treatment, Recurrence