Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology

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pISSN 2288-0585 eISSN 2288-6850

Antimicrobial Activities of Arbekacin against Recent Isolates of Staphylococcus aureus in Korean Hospitals

Original article

Annals of Clinical Microbiology (Ann Clin Microbiol) 2006 April Volume 9, Issue 1, pages 13-17.


https://doi.org/10.5145/ACM.2006.09.1.13

Antimicrobial Activities of Arbekacin against Recent Isolates of Staphylococcus aureus in Korean Hospitals

Sun Min Lee1 , Eun Joo Song1, Eun Kyoung Yang1, Il Kwon Bae2, Seok Hoon Jeong2, Jeong Man Kim3, Eun Yup Lee1 , and Chulhun L. Chang1
Department of Laboratory Medicine1, Pusan National University College of Medicine; Department of Laboratory Medicine2, Kosin University College of Medicine; and Department of Laboratory Medicine3, Dong-A University College of Medicine, Busan, Korea

Abstract

Background: As clinical isolates of Staphylococcus aureus with reduced inhibition zone of arbekacin in disk diffusion susceptibility tests are observed frequently, we examined their susceptibility to the antibiotic by comparing the results of the agar dilution testing with those of disk diffusion testing.

Methods: During the period of May through July, 2004, 88 isolates of methicillin-resistant and 11 methicillin-susceptible S. aureus were collected from clinical specimens in Pusan National University Hospital and Kosin University Gospel Hospital. Minimal inhibitory concentrations (MICs) of arbekacin were determined by the agar dilution method, and inhibition zones by the disk diffusion method.

Results: All of the 99 isolates were tested susceptible to arbekacin by the agar dilution method (MIC≤8mg/L). By the disk diffusion method, however, 5 isolates (5.1%) were intermediate (minor error) and 2 isolates (2.0%) resistant (major error).

Conclusion: All isolates were susceptible to arbekacin, but the disk diffusion method showed 7 per cent of minor or major errors.(Korean J Clin Microbiol 2006;9(1):13-17)

Keywords

Staphylococcus aureus, Arbekacin resistance, Disk diffusion