Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology


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pISSN 2288-0585 eISSN 2288-6850

A Case of Fungal Keratitis Caused by Colletotrichum Species

Case report

Annals of Clinical Microbiology (Ann Clin Microbiol) 2006 December Volume 9, Issue 2, pages 131-136.

A Case of Fungal Keratitis Caused by Colletotrichum Species

Sang Hoon Song1, Joon Jeong Park2, Kyo Sun Shin1, Sae Ik Joo1, Gwang Ja Lee2 , Kyoo Won Lee2, Hyun Lee1, and Eui Chong Kim1
Department of Laboratory Medicine1, Seoul National University Hospital, Seoul; and Department of Ophthalmology2, Cheil Eye Hospital, Daegu, Korea


Colletotrichum is mainly a fungal pathogen of plants, but sporadic cases of human infection have been reported recently. Most of them are fungal keratitis and only a few cases have been reported worldwide. A 63-year-old female farmer developed foreign body sensation and watering in her left eye following trauma by rice leaves. At presentation, her visual acuity decreased and corneal ulcer and inflammation in anterior chamber were observed on a slit lamp examination. Numerous hyphae were found on Gram stain and a rapidly growing mold with cup-shaped acervuli and falcate and nonseptate conidia was observed on fungal culture. As morphological findings did not lead to definite differentiation of the organism, sequencing of the D1-D2 domain of 28S rDNA was performed. It proved to be Colletotrichum species and the patient was treated with amphotericin and natamycin eye drop, but complicated by acute glaucoma. This is the first report of Colletotrichum keratitis in Korea and suggests that its infection should be considered in patients with fungal keratitis. (Korean J Clin Microbiol 2006;9(2):131-136)


Colletotrichum, Fungal keratitis, 28S rDNA sequencing