Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology

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pISSN 2288-0585 eISSN 2288-6850

RNAi: A Recent Revolutionary Tool for Understanding of Basic Biology

Review article

Annals of Clinical Microbiology (Ann Clin Microbiol) 2007 April Volume 10, Issue 1, pages 1-5.


https://doi.org/10.5145/ACM.2007.10.1.1

RNAi: A Recent Revolutionary Tool for Understanding of Basic Biology

Dong Kil Jung1, Young Suk Cho2, Won Kil Lee3
1Department of Laboratory Medicine, Hongseong Medical Center, 2Samkwang Medical Laboratory, Samkwang Medical Science Institute, Seoul; 3Department of Clinical Pathology, School of Medicine, Kyungpook National University, Daegu, Korea

Abstract

RNA interference (RNAi) is a gene-silencing technology by which small double-stranded RNAs are used to target the degradation of RNA with complementary sequence. RNAi is found in a wide variety of organisms (Caenorhabditis elegans, insects, plants, microorganisms and animals). With RNAi, we have harnessed the gene function to be explored, revolutionized our ability to perform large-scale genetic screens, and even therapeutic potential. (Korean J Clin Microbiol 2007;10:1-5)

Keywords

RNAi, Gene-silencing, Gene function, Therapeutic potential