Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology


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Indexed in KCI, KoreaMed, Synapse, DOAJ
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pISSN 2288-0585 eISSN 2288-6850

In Vitro Antimicrobial Activities of NanoSilver-coated Gauze against Clinical Isolates

Original article

Annals of Clinical Microbiology (Ann Clin Microbiol) 2007 April Volume 10, Issue 1, pages 37-43.

In Vitro Antimicrobial Activities of NanoSilver-coated Gauze against Clinical Isolates

Young Uh, Gyu Yul Hwang, Kap Jun Yoon, Hyo Youl Kim1, Hong Sun Uh2, O Kab Kwon3
Departments of Laboratory Medicine and 1Infectious Diseases, Yonsei University Wonju College of Medicine, Wonju; 2Uh Urologic Clinic, 3Nepes Corporation, Seoul, Korea


Background: It is well-known that silver ions and silver compounds are broad-spectrum antimicrobial agents effective against gram-positive and gram-negative bacteria, and yeasts. Thus, silver ions, as an antibacterial agent, have been used in the components of materials used in medical devices or coatings. Recently, advances in nanotechnology have enabled manufacturers to develop silver particles of a nanometer size with a safer and more effective antimicrobial activity. So, we evaluate the antimicrobial activity of nanoSilver-coated gauze against clinical isolates. 

Methods: Three kinds of nanoSilver-coated gauzes (100Å, 800Å, and 1,500Å) were tested for antimicrobial activity by the disk diffusion method. The organisms tested included clinical isolates of nonfermentative gram-negative bacilli (143 isolates), aerobic gram- negative bacteria (188), aerobic gram-positive bacteria (397), anaerobic bacteria (46), and yeasts (161), and three reference ATCC strains. 

Results: The susceptible rates to NanoSilver of nonfermentative gram-negative bacilli (NFB), aerobic gram- negative bacteria and aerobic gram-positive bacteria were 87%, 87% and 78%, respectively. Antimicrobial activity of NanoSilver against imipenem-resistant NFB, extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae, and methicillin-resistant Staphylcoccus aureus (MRSA) was similar to that against imipenem-sensitive NFB, ESBL non-producing Enterobacteriaceae, and methicillin-susceptible S. aureus

Conclusion: NanoSilver-coated gauze exhibits broad spectrum antimicrobial activities to a large number of gram-negative and gram-positive bacteria including imipenem-resistant NFB, ESBL producing Enterobacteriaceae, and MRSA. (Korean J Clin Microbiol 2007; 10:37-43)


Silver nanoparticle, Antimicrobial activity, Nonfermentative gram-negative bacilli, Gram-positive bacteria, Gram-negative bacteria