Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology

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pISSN 2288-0585 eISSN 2288-6850

Mechanisms of Acquiring Carbapenem-resistance in Acinetobacter Species

Review article

Annals of Clinical Microbiology (Ann Clin Microbiol) 2009 March, Volume 12, Issue 1, pages 1-5

https://doi.org/10.5145/ACM.2009.12.1.1

Mechanisms of Acquiring Carbapenem-resistance in Acinetobacter Species

Seok Hoon Jeong

Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea

Abstract

A rapid dissemination of carbapenem-resistant Acinetobacter spp. represents a significant clinical threat. Production of OXA carbapenemases and metallo-β- lactamases (MBLs) is the most important mechanism in acquiring carbapenem resistance in Acinetobacter spp. Carbapenem resistance has also ascribed to non- enzymatic mechanisms, including changes in outer membrane proteins, alterations in the affinity or expression of penicillin-binding proteins, and overexpression of efflux pumps. The most important mechanism in A. baumannii isolates from Korea is the production of OXA-23, while that in other species of Acinetobacter is the production of metallo-β-lactamases. (Korean J Clin Microbiol 2009;12:1-5)

Keywords

Acinetobacter, OXA carbapenemase, OXA- 51, OXA-23, Metallo-β-lactamase, Outer membrane protein, AdeABC efflux pump