Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology

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pISSN 2288-0585 eISSN 2288-6850

T Types, emm Genotypes and Antibiotic Resistance of Streptococcus pyogenes Isolated from School Children in Jinju, 2006

Original article

Annals of Clinical Microbiology (Ann Clin Microbiol) 2009 March, Volume 12, Issue 1, pages 6-10.

https://doi.org/10.5145/ACM.2009.12.1.6

T Types, emm Genotypes and Antibiotic Resistance of Streptococcus pyogenes Isolated from School Children in Jinju, 2006

Eun-Ha Koh, In-Suk Kim, Sunjoo Kim

Department of Laboratory Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea

Abstract

Background: Streptococcus pyogenes is the most common cause of bacterial pharyngitis. T antigens and emm genotypes are essential markers for an epidemiological study of S. pyogenes. Macrolide resistance of S. pyogenes is a serious obstracle to successfully treating a sore throat. 

Methods: One-hundred forty-seven strains of S. pyogenes isolated from healthy school children in 2006 were subjected to T typing and emm genotyping. A disk diffusion method was applied for several antibiotics. A double disk diffusion test was performed to evaluate the phenotype distribution of macrolide resistance. 

Results: Among T antigens and emm genotypes, T11 (19.7%) and emm78 (16.7%), respectively, were the most common in 2006. Both T5/27/44 (2.3%) and emm44/61 (9.1%) declined to a great extent from about 29% in 2004. The rate of resistance to antibiotics were 11.6% to erythromycin, 4.8% to clindamycin, 21.8% to tetracycline, and 7.5% to ofloxacin. M and cMLSB phenotypes were 52.9% and 41.2% respectively. 

Conclusion: T typing and emm genotyping proved a dynamic change in their distribution in 2006 compared to the results of 2004. Erythromycin and clindamycin resistance remained low as in 2004, whereas ofloxacin resistance increased slightly. M and cMLSB phenotypes were equivalent in 2006, whereas cMLSB was predominant in 2004. (Korean J Clin Microbiol 2009;12:6-10)

Keywords

Streptococcus pyogenes, T type, Erythromycin resistance, emm, Sore throat, Pharyngitis