Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology


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Indexed in KCI, KoreaMed, Synapse, DOAJ
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pISSN 2288-0585 eISSN 2288-6850

Metallo-β-lactamase Producing Gram-negative Bacilli

Review article

Annals of Clinical Microbiology (Ann Clin Microbiol) 2009 September, Volume 12, Issue 3, pages 103-109.

Metallo-β-lactamase Producing Gram-negative Bacilli

Dongeun Yong

Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea


Among gram-negative bacteria, rate of antibiotic resistance has been increasing. As a result, carbapenem is now considered as a last resort of therapeutic regimens for gram-negative bacterial infections. The choice of antibiotics has been impeded by the spread of organisms producing metallo-β-lactamases (MBL), which can confer resistance to nearly all β-lactams. MBLs have extremely diverse structures and are carried by various organisms including human pathogens. This review will focus on the classification and current status of MBL reported in Korea. (Korean J Clin Microbiol 2009;12:103-109)


Metallo-β-lactamase, Gram-negative bacilli