Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology

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pISSN 2288-0585 eISSN 2288-6850

Perineal Colonization Rate and Antimicrobial Susceptibility of Group B Streptococcus in Pregnant and Non-Pregnant Korean Women

Original article

Annals of Clinical Microbiology (Ann Clin Microbiol) 2009 December, Volume 12, Issue 4, pages 180-185.

https://doi.org/10.5145/ACM.2009.12.4.180

Perineal Colonization Rate and Antimicrobial Susceptibility of Group B Streptococcus in Pregnant and Non-Pregnant Korean Women

Sun-Hwa Lee1, Kyoung Un Park2, Hae-Kyung Lee3, Mi Young Kim1, Jin Yong Kim1, Won Kyoung Kwon1, Lee Sun Park1
Department of Laboratory Medicine, 1Neodin Medical Institute, Seoul, 2Seoul National University Bundang Hospital, Seongnam, 3The Catholic University of Korea College of Medicine, Seoul, Korea

Abstract

Background: Group B Streptococcus (Streptococcus agalactiae, GBS) is a major cause of severe infections in neonates, including bacteremia, pneumonia, and meningitis, and is generally vertically transmitted from a colonized, pregnant woman to her infant. Penicillin is the drug of choice to treat GBS infections, because GBS strains are uniformly susceptible to penicillin. Recently, however, penicillin resistant GBS strains have been reported and the rates of erythromycin and clindamycin resistance have increased. We evaluated the perineal colonization rates and antimicrobial susceptibility of GBS strains isolated from pregnant and non-pregnant women.

Methods: The antibiotic susceptibilities of a total of 180 GBS strains isolated from two university hospitals and one reference laboratory between May 2008 and January 2009 were determined using disk diffusion and broth microdilution methods. The presence of erythromycin resistance genes was confirmed by PCR.

Results: The average colonization rate of pregnant women was 5.5%. The overall colonization rates of pregnant and non-pregnant women ranged between 5.5% and 7.5%. All 180 GBS strains were susceptible to penicillin. Fifty strains (27.8%) were resistant to erythromycin, whereas 78 (41.1%) were resistant to clindamycin. The ermB gene was identified in 40 isolates and 44 isolates had constitutive macrolide- lincosamide-streptogramin B resistance phenotypes.

Conclusion: Our findings indicate an increased GBS colonization rate and an increase in macrolide resistance in GBS strains in recent years, emphasizing the need for further surveillance and continual monitoring of antimicrobial susceptibility. (Korean J Clin Microbiol 2009;12:180-185)

Keywords

GBS, Group B streptococcus, Colonization rate, Antimicrobial susceptibility