Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology


Weeks in Review


Weeks to Publication
Indexed in KCI, KoreaMed, Synapse, DOAJ
Open Access, Peer Reviewed
pISSN 2288-0585 eISSN 2288-6850

A Fatal Case of Candida orthopsilosis Fungemia

Case report

Annals of Clinical Microbiology (Ann Clin Microbiol) 2010 September, Volume 13, Issue 3, pages 140-143.

A Fatal Case of Candida orthopsilosis Fungemia

Hyun Jung Choi1, Jong Hee Shin1, Kyung Hwa Park2, Myung Geun Shin1, Soon Pal Suh1, Dong Wook Ryang1
Departments of 1Laboratory Medicine and 2Internal Medicine, Chonnam National University Medical School, Gwangju, Korea


Candida orthopsilosis is a recently described Candida species phenotypically indistinguishable from Candida parapsilosis. This new species can be identified only by using molecular methods. We describe here a fatal case of fungemia caused by C. orthopsilosis in a 75-year-old male patient who had panperitonitis after total gastrectomy with Roux-en-Y esophagojejunostomy. All 18 blood cultures obtained from admission day 16 to day 68 yielded the same Candida species. Both Vitek 2 (bioMerieux, Inc., Hazelwood, MO, USA) and API 20C (bioMerieux, Marcy-l’Etoile, France) failed to identify these isolates. However, DNA sequencing analysis of both D1/D2 domain and internal transcribed spacer region of rDNA showed 100% identity with C. orthopsilosis. The fungemia was persistent over 50 days despite of systemic antifungal therapy including fluconazole and caspofungin, and the patient expired on day 73 of his hospital stay. This represents the first reported case of fatal fungemia by C. orthopsilosis in Korea. (Korean J Clin Microbiol 2010;13:140-143)


C. orthopsilosis, Fungemia, DNA sequencing