Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology

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pISSN 2288-0585 eISSN 2288-6850

Distribution and Antimicrobial Resistance of Streptococcus pneumoniae at Four University Hospitals in Busan and Gyeongnam

Original article

Annals of Clinical Microbiology (Ann Clin Microbiol) 2016 June, Volume 19, Issue 2, pages 48-53.

https://doi.org/10.5145/ACM.2016.19.2.48

Distribution and Antimicrobial Resistance of Streptococcus pneumoniae at Four University Hospitals in Busan and Gyeongnam

Si Hyun Kim1,2*, Sae Am Song1*, Jongyoun Yi3, Duyea Song1,3, Chulhun Ludgerus Chang3, Dong-Chul Park1, Sang-Hwa Urm4, Hye Ran Kim1, Jeong Hwan Shin1,2
1Department of Laboratory Medicine and 2Paik Institute for Clinical Research, Inje University College of Medicine, Busan, 3Department of Laboratory Medicine, Pusan National University School of Medicine, Yangsan, 4Department of Preventive Medicine, Inje University College of Medicine, Busan, Korea

Abstract

Background: Streptococcus pneumoniae is the most common human pathogen causing community-acquired pneumonia. There is little information on the recent antimicrobial susceptibility patterns of S. pneumoniae in Busan and Gyeongnam of Korea. The aim of this study was to investigate the distribution and antimicrobial resistance of S. pneumoniae at 4 university hospitals in Busan and Gyeongnam.

Methods: We collected and analyzed the antimicrobial susceptibility results of 850 S. pneumoniae strains isolated from regional 4 university hospitals during the last 2 years from July 2013 through June 2015.

Results: Among 850 S. pneumoniae strains, 635 strains were isolated from respiratory specimens, followed by blood (N=121), CSF (N=13), and others (N=81). Antimicrobial susceptibility rates to penicillin, cefotaxime and ceftriaxone were 79.4%, 76.6% and 83.6%, respectively. The resistant rates to erythromycin and clindamycin were 80.9% and 68.2%, respectively. The resistant rates to levofloxacin were 9.2%. There were some differences in resistant rates by age groups, years, and specimen types.

Conclusion: We found the changes of antimicrobial resistance of S. pneumoniae during the last 2 years. It is necessary to monitor the antimicrobial susceptibility of S. pneumoniae regularly for empirical therapy and for early detection of the changes of resistance. (Ann Clin Microbiol 2016;19:48-53)

Keywords

Drug resistance, Multiple, Streptococcus pneumoniae