Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology

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pISSN 2288-0585 eISSN 2288-6850

High Prevalence of Rotavirus G4P[6] Genotypes among Neonates in Two Korean Hospitals

Original article

Annals of Clinical Microbiology (Ann Clin Microbiol) 2017 September, Volume 20, Issue 3, pages 63-66.

https://doi.org/10.5145/ACM.2017.20.3.63

High Prevalence of Rotavirus G4P[6] Genotypes among Neonates in Two Korean Hospitals

Jae-Seok Kim1, Sung Mi Kim2, Hyun Soo Kim1
1Department of Laboratory Medicine, Hallym University College of Medicine, Hwaseong, 2Department of Pediatrics, Busan Saint Mary Hospital, Busan, Korea

Abstract

Background: The introduction of rotavirus vaccines has decreased the prevalence of rotavirus infections and might have changed the distribution of rotavirus genotypes. However, neonates are not eligible for vaccination and, therefore, are at risk for rotavirus infection while in the hospital nursery or neonatal intensive care unit. Our aim was to evaluate the shift of genotypes of group A rotavirus strains among neonates cared for in two geographically distant hospitals in Korea.

Methods: Analysis of rotavirus P and G genotypes was performed for 63 neonates (27 neonates in Seoul and 36 neonates in Busan) admitted to two hospitals between 2011 and 2013.

Results: Among the 63 tested neonates less than one month of age, 61 (96.8%) were infected with genotype G4P[6].

Conclusion: This study identified G4P[6] as the most frequently isolated genotypes among neonates in Korea; therefore, prevention of the G4P[6] genotype should be considered for neonates. (Ann Clin Microbiol 2017;20:63-66)

Keywords

Genotype, Neonates, Nursery, Prevention, Rotavirus, Vaccine