Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology

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pISSN 2288-0585 eISSN 2288-6850

Challenges of Scaling Up SARS-CoV-2 Rapid Antigen Tests

Original article

Annals of Clinical Microbiology (Ann Clin Microbiol) 2021 March, Volume 24, Issue 1, pages 111-114.

https://doi.org/10.5145/ACM.2021.24.4.1

Challenges of Scaling Up SARS-CoV-2 Rapid Antigen Tests

Mi-Kyung Lee

Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea

Abstract

The current reference standard for the diagnosis of coronavirus disease 2019 (COVID-19) is the molecular detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Several rapid antigen tests (RATs) have been developed for the rapid and inexpensive detection of SARS-CoV-2, which can be used at the point-of-care. Although RATs have lower SARS-CoV-2 detection sensitivity than molecular tests, the development of a more cost-effective highthroughput test system that offers a rapid turnaround time is vital for curtailing the spread of SARS-CoV-2. However, because of the growing concern over the substantial risk of false negative results, RATs should be used in conjunction with molecular tests and therefore, an appropriate test algorithm should be developed to achieve this purpose.

Keywords

Rapid antigen tests, SARS-CoV-2