Osteomyelitis caused by Salmonella Typhi is rare in an otherwise healthy person. Here, we describe a case of Salmonella osteomyelitis in a sternoclavicular joint mimicking malignancy or tuberculosis, in an immunocompetent patient. Salmonella infection should be included in the differential diagnosis of osteomyelitis, especially in patients with a previous history of diarrhea. (Korean J Clin Microbiol 2006;9(2):146-148)