Table 2. Categorical agreement and error rates between the reference method and the Sensititre SLOMYCO panel
Ann Clin Microbiol 2025;28(4):24. Drug susceptibility testing of Mycobacterium avium complex using the SLOMYCO test-system: a diagnostic accuracy study Download table Antimicrobials No. of isolates tested % Categorical agreement (95% CI) Very major error (VME, %) Major error (ME, %) Minor error (mE, %) Amikacin 86 77.9 (68.0-85.4) 0 2.3 19.8 Clarithromycin 86 100.0 (95.7-100.0) […]
Table 1. Comparison of MICs and EA between the reference broth microdilution and Sensititre SLOMYCO panel for mycobacterial isolates
Ann Clin Microbiol 2025;28(4):24. Drug susceptibility testing of Mycobacterium avium complex using the SLOMYCO test-system: a diagnostic accuracy study Download table Antimicrobials Method No. of isolates with each MIC (µg/mL) No. of isolates included for the EA calculation EA (%) 95% CI of EA Amikacin MIC ≤1 1 2 4 8 16 32 64 >64 […]
Table 4. Functions of resistance-associated genes and drug resistance mechanisms in Mycobacterium tuberculosis [20]
Ann Clin Microbiol 2025;28(4):26. Drug susceptibility testing for Mycobacterium tuberculosis: a narrative review Download table WHO category Drug or drug class Resistance gene Gene function Mechanism of drug resistance First-line agents Rifampicin rpoB RNA polymerase Target modification Isoniazid katG Catalase-peroxidase enzyme Decreased drug activation inhA NADH-dependent enoyl-acyl carrier protein Target amplification or modification Pyrazinamide pncA […]
Table 3. Critical concentrations of drugs recommended for treating drug-susceptible and multidrug- or rifampicin-resistant tuberculosis
Ann Clin Microbiol 2025;28(4):26. Drug susceptibility testing for Mycobacterium tuberculosis: a narrative review Download table Category Drug Critical concentrations (μg/mL) by medium LJ Middlebrook 7H10 Middlebrook 7H11 MGIT Drug-susceptible TB First-line drugs Rifampicin 40.0 0.5 1.0 0.5 Isoniazid 0.2 0.2 0.2 0.1 Ethambutola) 2.0 5.0 7.5 5.0 Pyrazinamidea) – – – 100.0 MDR/RR-TB […]
Table 2. Classification of drugs used in multidrug- and rifampicin-resistant tuberculosis treatment regimens in Korea [5]
Ann Clin Microbiol 2025;28(4):26. Drug susceptibility testing for Mycobacterium tuberculosis: a narrative review Download table Group Anti-TB drug A Levofloxacin or MoxifloxacinBedaquilineDelamanidLinezolid B CycloserineClofazimine C Amikacin or Kanamycin (Streptomycin)EthambutolImipenem-cilastatin or MeropenemPara-aminosalicylc acid (PAS)ProthionamidePyrazinamide Group A: Highly effective core medicines that should be included in all longer MDR/RR-TB regimens unless contraindicated due to toxicity, intolerance, or […]
Table 1. Drug-resistant tuberculosis classifications
Ann Clin Microbiol 2025;28(4):26. Drug susceptibility testing for Mycobacterium tuberculosis: a narrative review Download table Drug-resistance Description Isoniazid-resistant TB (rifampicin-susceptible) (Hr-TB) Tuberculosis caused by Mycobacterium tuberculosis strains that are resistant to isoniazid but remain susceptible to rifampicin. Rifampicin-resistant TB (RR-TB) TB caused by strains resistant to rifampicin, with or without resistance to other first-line drugs. […]
Whole-genome sequencing as the new framework of clinical microbiology and highlights in this issue
Editorial Hae-Sun Chung Department of Laboratory Medicine, Ewha Womans University College of Medicine, Seoul, Korea Correspondence to Hae-Sun Chung, E-mail: sunny0521.chung@ewha.ac.kr Ann Clin Microbiol 2025;28(4):27. https://doi.org/10.5145/ACM.2025.28.4.8Received on 16 December 2025, Revised on 18 December 2025, Accepted on 18 December 2025, Published on 20 December 2025.Copyright © Korean Society of Clinical Microbiology.This is an Open Access […]
Drug susceptibility testing for Mycobacterium tuberculosis: a narrative review
Review article Chang-Ki Kim Department of Laboratory Medicine, Seoul Clinical Laboratories, Yongin, Korea Correspondence to Chang-Ki Kim, E-mail: psoas95@gmail.com Ann Clin Microbiol 2025;28(4):26. https://doi.org/10.5145/ACM.2025.28.4.7Received on 7 December 2025, Revised on 14 December 2025, Accepted on 15 December 2025, Published on 20 December 2025.Copyright © Korean Society of Clinical Microbiology.This is an Open Access article which […]
Clinical evaluation of GenBody hMPV Ag Rapid Test: a diagnostic accuracy study
Original article Sungwook Song, Eunsim Shin, Sunghee Han, Sang Gon Lee Laboratory Medicine Center, Division of Laboratory Medicine, GC Labs, Yongin, Korea Correspondence to Sungwook Song, E-mail: song1221@gclabs.co.kr Ann Clin Microbiol 2025;28(4):25. https://doi.org/10.5145/ACM.2025.28.4.6Received on 26 September 2025, Revised on 9 December 2025, Accepted on 10 December 2025, Published on 20 December 2025.Copyright © Korean Society […]
Drug susceptibility testing of Mycobacterium avium complex using the SLOMYCO test-system: a diagnostic accuracy study
Original article Jeong Su Park1*, Kyu-Hwa Hur2*, Woo Jin Shin1, Hyunji Kim1, Dong Woo Shin1, Kyoung Un Park1 1Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea2Department of Laboratory Medicine, Green Cross Laboratories, Yongin, Korea*These authors contributed equally to this work. Correspondence to Jeong Su Park, E-mail: […]