Annals of Clinical Microbiology, The official Journal of the Korean Society of Clinical Microbiology

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pISSN 2288-0585 eISSN 2288-6850

Aminoglycoside Resistance in Gram-negative Bacilli

Review article

Annals of Clinical Microbiology (Ann Clin Microbiol) 2009 June, Volume 12, Issue 2, pages 57-61.

https://doi.org/10.5145/ACM.2009.12.2.57

Aminoglycoside Resistance in Gram-negative Bacilli

Yeon-Joon Park

Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea

Abstract

Aminoglycosides are one of the clinically relevant antibiotics. They kill bacteria by binding to bacterial 30S subunit of ribosome. Resistance to aminoglycosides occurs by three different mechanisms: 1. Production of an enzyme that modifies aminoglycosides, 2. Impaired entry of aminoglycoside into the cell by altering the OMP permeability, decreasing inner membrane transport, or active efflux, 3. The receptor protein on the 30S ribosomal subunit may be deleted or altered as a result of a mutation. By far, enzymatic modification has been the most important mechanism. In this review, the mechanisms of action and resistance, and the prevalence of resistance due to acquisition of enzymes are briefly described. (Korean J Clin Microbiol 2009;12:57-61)

Keywords

Aminoglycoside resistance, Gram negative aerobic rods, 30S ribosome subunits