Original article Heejung Kim Department of Laboratory Medicine, Yonsei University, Yongin Severance Hospital, Yongin, Korea Correspondence to Heejung Kim, E-mail: hjkim12@yuhs.ac Ann Clin Microbiol 2025;28(3):14. https://doi.org/10.5145/ACM.2025.28.3.3Received on 15 May 2025, Revised on 5 August 2025, Accepted on 5 August 2025, Published on 20 September 2025.Copyright © Korean Society of Clinical Microbiology.This is an Open Access article which is freely available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/). Abstract Background: Accurate diagnosis of Clostridioides difficile infection (CDI) requires both microbiologic confirmation and clinical correlation. Current guidelines recommend a two-step algorithm combining a sensitive screening test with a specific confirmatory assay. This study evaluated the diagnostic performance of the glutamate dehydrogenase (GDH)/toxin enzyme immunoassay (EIA) over five years and assessed its suitability as an initial screening test. Methods: We retrospectively analyzed 8,685 C. difficile-related tests conducted between March 2020 to February 2025. The GDH/toxin EIA was performed using

Original article Young Ah Kim1, Heejung Kim2,3, Dokyun Kim3, Changseung Liu3, Seok Hoon Jeong3 1Department of Laboratory Medicine, National Health Insurance Service Ilsan Hospital, Goyang, 2Department of Laboratory Medicine, Yongin Severance Hospital, YongIn, 3Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea Corresponding to Heejung Kim, E-mail: hjkim12@yuhs.ac Ann Clin Microbiol 2022;25(1):17-23. https://doi.org/10.5145/ACM.2022.25.1.3Received on 16 February 2022, Revised on 8 March 2022, Accepted on 14 March 2022, Published on 20 March 2022.Copyright © Korean Society of Clinical Microbiology.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: There has been a marked increase in the mortality rate associated with Clostridioides difficile infection (CDI) globally since 2003, with the emergence of binary toxinproducing ribotype 027

Original article Young Ah Kim1, Heejung Kim2, Dokyun Kim2, Changseung Liu3, Seok Hoon Jeong2 1Department of Laboratory Medicine, National Health Insurance Service, Ilsan Hospital, Goyang, 2Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, 3Department of Laboratory Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea Corresponding to Heejung Kim, E-mail: hjkim12@yuhs.ac Ann Clin Microbiol 2022;25(2):47-52. https://doi.org/10.5145/ACM.2022.25.2.3Received on 15 March 2022, Revised on 27 April 2022, Accepted on 27 April 2022, Published on 20 June 2022.Copyright © Korean Society of Clinical Microbiology.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The incidence of community-associated (CA) Clostridioides difficile infection (CDI) has increased in Korea. In this study, we evaluated CA-CDI risk factors